Clinical Trials

The purpose of this study is to develop a test for axial movements in the horizontal position, then determine if it improves after the diagnostic tap test and can be used as a prognostic indicator for shunt surgery.

The purpose of this study is to compare Medical Therapy (MT) vs. MT Plus Optic Nerve Sheath Fenestration vs. MT Plus Ventriculoperitoneal Cerebrospinal Fluid Shunting in subjects with idiopathic intracranial hypertension and moderate-to-severe visual loss. 

The purpose of this study is to collect data to objectively monitor the clinical outcomes of patients following CSF shunting for the treatment of idiopathic normal pressure hydrocephalus in order to optimize the surgical care of patients with this disease.

The purpose of this study is to further characterize the serum and Cerebral Spinal Fluid (CSF) biomarker profile of idiopathic normal pressure hydrocephalus, both before and after VP shunt placement, and help differentiate this profile from Alzheimer’s disease.

In this pilot study the investigators shall prospectively in a blinded fashion evaluate with AB PET and CSF AB42 and tTau or pTau in patients committed to shunt surgery and then investigate the relationship of these biomarkers with outcome on gait, cognition and urinary control improvement in the short term (3 months) and long term (1 year). The imaging agent will be provided by AVID.

Furthermore the study will standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden.