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A Study to Develop a Horizontal Axial Movement Test for Use Before and After Shunt Treatments in Patients who have Normal Pressure Hydrocephalus
Jacksonville, FL
The purpose of this study is to develop a test for axial movements in the horizontal position, then determine if it improves after the diagnostic tap test and can be used as a prognostic indicator for shunt surgery.
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A Study to Compare Surgical Idiopathic Intracranial Hypertension Treatment
Rochester, MN
The purpose of this study is to compare Medical Therapy (MT) vs. MT Plus Optic Nerve Sheath Fenestration vs. MT Plus Ventriculoperitoneal Cerebrospinal Fluid Shunting in subjects with idiopathic intracranial hypertension and moderate-to-severe visual loss.
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Clinical Outcomes Following Shunting for Idiopathic Normal Pressure Hydrocephalus (iNPH)
Rochester, MN
The purpose of this study is to collect data to objectively monitor the clinical outcomes of patients following CSF shunting for the treatment of idiopathic normal pressure hydrocephalus in order to optimize the surgical care of patients with this disease.
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Cerebral Spinal Fluid Evaluation in Individuals Who Have Idiopathic Normal Pressure Hydrocephalus (INPH)
Rochester, MN
The purpose of this study is to further characterize the serum and Cerebral Spinal Fluid (CSF) biomarker profile of idiopathic normal pressure hydrocephalus, both before and after VP shunt placement, and help differentiate this profile from Alzheimer’s disease.
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A Study to Establish a Registry for Treatment of Post-hemorrhagic Hydrocephalus in Neonates
Rochester, MN
The purpose of this study is to establish a prospective, standardized data collection for the patients who undergo surgical treatment of progressive post-hemorrhagic hydrocephalus in neonates with the focus on comparing neuroendoscopic lavage (NEL) with other standard treatment options such as external ventricular drainage (EVD), ventricular access device (VAD) and ventricular subgaleal shunt (VSGS).
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Efficacy in iNPH Shunting (PENS) Trial
Rochester, MN
The Placebo-Controlled Efficacy in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is an investigation of cerebrospinal fluid (CSF) shunt surgery to study the shunt effectiveness in iNPH patients.
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Prognostic Value Of Aβ Imaging In NPH Prior To Shunt Placement
Jacksonville, FL
In this pilot study the investigators shall prospectively in a blinded fashion evaluate with AB PET and CSF AB42 and tTau or pTau in patients committed to shunt surgery and then investigate the relationship of these biomarkers with outcome on gait, cognition and urinary control improvement in the short term (3 months) and long term (1 year). The imaging agent will be provided by AVID.
Furthermore the study will standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden.