Clinical Trials

The purpose of this study is to develop a test for axial movements in the horizontal position, then determine if it improves after the diagnostic tap test and can be used as a prognostic indicator for shunt surgery.

The purpose of this study is to compare Medical Therapy (MT) vs. MT Plus Optic Nerve Sheath Fenestration vs. MT Plus Ventriculoperitoneal Cerebrospinal Fluid Shunting in subjects with idiopathic intracranial hypertension and moderate-to-severe visual loss. 

The purpose of this study is to establish a prospective, standardized data collection for the patients who undergo surgical treatment of progressive post-hemorrhagic hydrocephalus in neonates with the focus on comparing neuroendoscopic lavage (NEL) with other standard treatment options such as external ventricular drainage (EVD), ventricular access device (VAD) and ventricular subgaleal shunt (VSGS).

In this pilot study the investigators shall prospectively in a blinded fashion evaluate with AB PET and CSF AB42 and tTau or pTau in patients committed to shunt surgery and then investigate the relationship of these biomarkers with outcome on gait, cognition and urinary control improvement in the short term (3 months) and long term (1 year). The imaging agent will be provided by AVID.

Furthermore the study will standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden.