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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-9 of 9 for Aortic valve repair and aortic valve replacement

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  • Study status: Open/Status Unknown
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  1. Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

    Rochester, MN

  2. PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban

    Rochester, MN

  3. PROTECTED TAVR: Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement

    Rochester, MN

  4. The PARTNER 3 - AVIV Trial

    Rochester, MN

  5. Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis

    Rochester, MN

  6. International Bicuspid Aortic Valve Consortium (BAVCon)

    Rochester, MN

  7. A Study to Evaluate Proximal Aortic Seal Zone Stress and Strain Following Endovascular Aortic Repair

    Jacksonville, FL

  8. A Study to Evaluate Aortic Dilatation in Patients with Conotruncal Abnormalities

    Rochester, MN

  9. A Study to Collect Serum Samples from Patients Presenting for Aortic Valve Replacement

    Rochester, MN

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