Inclusion Criteria:

- Moderate AS, defined as follows by transthoracic echo (TTE) at rest:

- Max aortic velocity ≥ 3.0 m/sec and < 4.0 m/sec; and

- Mean aortic gradient ≥ 20.0 mmHg and < 40.0 mmHg; and

- AVA > 1.0 cm^2 and < 1.5 cm^2.

- NYHA class ≥ II and symptoms of AS, including but not limited to:

- Dyspnea at rest or on exertion;

- Fatigue;

- Angina;

- Syncope in the absence of another identifiable cause;

- LVEF > 20% by 2-D echo.

- Any of the following:

- HF event or hospitalization within 1 calendar year prior to qualifying echo;

- NT proBNP ≥ 600 pg/ml (or BNP 80 pg/ml) measured within 6 months prior to or
within 2 weeks after qualifying echo;

- Global longitudinal strain ≤ 15% (absolute value) at qualifying echo; or

- E/e' (average of medial and lateral velocities) ≥ 14.0 at qualifying echo.

Exclusion Criteria:

- Age < 65 years

- Class I indication for cardiac surgery.

- Sievers Type 0 or Type 2 bicuspid aortic valve or Sievers Type 1 bicuspid aortic valve
with ascending aorta diameter > 4.5 cm.

- Not anatomically suitable for transfemoral TAVR.

- In need of and suitable for coronary revascularization per Heart Valve Team.

- Documented history of cardiac amyloidosis.