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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 37 for Heart disease

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  • Study status: Open/Status Unknown
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  1. Cardiovascular Effects of Energy Drinks in Healthy Adults

    Rochester, MN

  2. A Study of Atrial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

    Jacksonville, FL

  3. A Study to Determine the Impact of Individualized Estrogen Therapy on Cardiovascular Disease Risk Parameters in Young Women after Bilateral Oophorectomy

    Rochester, MN

  4. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

    Scottsdale/Phoenix, AZ

  5. Diet, Vascular Health and the Gut Microbiome in Heart Failure

    Scottsdale/Phoenix, AZ

  6. Physiologic Effects of Sleep Restriction

    Rochester, MN

  7. Characterizing Heart Changes Related to Chemo-Radiotherapy

    Scottsdale/Phoenix, AZ

  8. A Study to Evaluate MUSIC Software for Imaging Integration into Electroanatomic Mapping for Catheter Ablation Procedures of Ventricular Arrhythmias

    Rochester, MN

  9. Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis

    Rochester, MN

  10. Myocardial Ischemia and Transfusion

    Rochester, MN

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