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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 20 for Heart valve disease

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  • Study status: Open/Status Unknown
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  1. Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

    Rochester, MN

  2. A Study to Evaluate the Edwards PASCAL Transcatheter Valve Repair System in Patients with Tricuspid Regurgitation

    Rochester, MN

  3. PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban

    Rochester, MN

  4. A Study to Evaluate a Computerized Stethoscope called ©CompuSteth to Diagnose Heart Disease

    Rochester, MN

  5. A Study to Compare Conventional Heart Echo Measurements with Newer 2 and 3 Dimensional Measurements of Mechanical Heart Strain after Trastuzumab Infusion

    Rochester, MN

  6. A Study to Evaluate the Safety and Effectiveness of Beating Heart Mitral Valve Repair with the HARPOON™ System

    Rochester, MN

  7. PROTECTED TAVR: Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement

    Rochester, MN

  8. A Study to Investigate the Safety and Effectiveness of SAPIEN 3 Transcatheter Heart Valve Implantation in Patients with a Failing Mitral Bioprosthetic Valve

    Rochester, MN

  9. A Study to Evaluate Mitral Implantation of Transcatheter Valves

    Rochester, MN

  10. Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients With AsYmptomatic Severe Aortic Stenosis

    Rochester, MN

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