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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1871-1880 of 10637

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  1. A Study of the Effects of Exendin-9,39 on Glucose Metabolism, Glucagon and Insulin Secretion, and on Insulin Action

    Rochester, MN

  2. A Study of the Safety and Effectiveness of TH-302 Combined with Gemcitabine and Compared with Gemcitabine Alone for Previously Untreated Patients with Pancreatic Adenocarcinoma

    Scottsdale/Phoenix, AZ, Rochester, MN

  3. A Study of Itacitinib (INCB039110) in Combination With Ibrutinib in Subjects With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

    Scottsdale/Phoenix, AZ

  4. A Study of Adding AMG 479 to First Line Chemotherapy in Patients with Optimally Debulked Epithelial Ovarian Cancer

    Rochester, MN

  5. A Study of Insulin Synthesis and Secretion in Pre-diabetes

    Rochester, MN

  6. Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia

    Rochester, MN

  7. A Phase IV Post Approval Clinical Study of ExAblate Treatment of Metastatic Bone Tumors for the Palliation of Pain

    Rochester, MN

  8. Insulin Deprivation on Brain Structure and Function in Humans With Type 1 Diabetes

    Rochester, MN

  9. Hypofractionated Radiotherapy After Breast Conserving Surgery

    Scottsdale/Phoenix, AZ, Rochester, MN, Jacksonville, FL

  10. Lidocaine as an Endotracheal Tube (ETT) Cuff Media

    Rochester, MN

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