Clinical Trials

Does Surgical Approach Affect Patient Satisfaction and Joint Awareness Following Total Hip Arthroplasty?

Rochester, MN

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Does Surgical Approach Affect Patient Satisfaction and Joint Awareness Following Total Hip Arthroplasty?

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to:

Determine patient reported outcomes following total hip arthroplasty based on surgical approach.
Determine if the Forgotten Joint Score (FJS)-12 has superior capability to discriminate outcomes in patients with THA compared to the modified Harris Hip Score (mHHS).

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

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Site IRB:
17-008126
Sponsor Protocol Number:
17-008126

Revision Knee Replacement for Flexion Instabiity

Rochester, MN

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Revision Knee Replacement for Flexion Instabiity

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

Revision TKA for instability is fairly common occurring in up to 22% of revision procedures. Previous reports of revision TKA for flexion instability are limited in the length of follow-up as well as the number of patients. There is a paucity of studies with large series of total knee arthroplasty patients revised for flexion instability with midterm and long-term follow-up. The purpose of this study is to present the Mayo Clinic series of revision TKA patients with flexion instability and present the clinical outcomes including survivorship, complications, reoperations as well as patient reported and radiographic outcomes at mid- to long-term follow-up.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

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Site IRB:
21-001046

Leveraging AI/ML Algorithms On Digital Pathology And Ex-Vivo Confocal Microscopy Imaging For Extramammary Paget’s Disease

Rochester, MN

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Leveraging AI/ML Algorithms On Digital Pathology And Ex-Vivo Confocal Microscopy Imaging For Extramammary Paget’s Disease

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to validate the use of ex-vivo confocal microscopy for the assessment of skin specimens derived from Mohs surgery compared to standard microscopy. To leverage deep learning models for classification, detection, and localization of tumor for extramammary Paget’s disease on ex-vivo confocal microscopy images. To leverage AI/ML to ex-vivo confocal microscopy imaging to facilitate microscopic-level imaging of extramammary Paget’s disease. To leverage deep learning models for classification, detection, and localization of tumor for extramammary Paget’s disease on frozen and permanent pathology WSIs.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Open for enrollment	View complete study & contact information

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Site IRB:
25-010037
Sponsor Protocol Number:
25-010037

Post-Surgical Based Efforts to Reduce Preventable Readmissions and Optimize Length of Stay

Rochester, MN

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Post-Surgical Based Efforts to Reduce Preventable Readmissions and Optimize Length of Stay

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The investigators believe that the lessons learned from studies regarding 30-day and 90-day readmission are primarily due to failure of early symptom recognition, and medical error. Through the aid of remote monitoring and early symptom detection, the hypothesis for the current proposal is that interventions can be recommended in an earlier, remote fashion that may result in earlier post-surgical discharge, prevent decompensation, and prevent increased readmissions that have been associated with decreased LOS in other surgical populations.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

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Site IRB:
21-000817
NCT ID:
NCT04881708

Study Of Intralesional Cemiplimab In Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

Scottsdale/Phoenix, AZ

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Study Of Intralesional Cemiplimab In Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
3
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

This study will test a study drug called cemiplimab to see if it can help treat early-stage Cutaneous Squamous Cell Carcinoma (CSCC), a type of skin cancer. Cemiplimab works by helping the immune system to kill cancer cells. It binds to a protein called Programmed cell Death-1 (PD-1) on the surface of certain immune cells.

The main purpose of this study is to compare how well cemiplimab works compared to surgery, when injected into the lesion.

The study is looking at:

* The side effects cemiplimab might cause
* How well cemiplimab works compared to surgery

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Scottsdale/Phoenix, AZ	Open for enrollment	View complete study & contact information

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Site IRB:
25-001705
NCT ID:
NCT06585410
Sponsor Protocol Number:
R2810-ONC-2251

A Study of the Effects of Synovial (Joint Lubricating) Fluid on the Development of Osteoarthritis

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A Study To Evaluate The Staple Line Control Of Bleeding For MicroCutter Assisted Thoracic Surgery

Rochester, MN

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A Study To Evaluate The Staple Line Control Of Bleeding For MicroCutter Assisted Thoracic Surgery

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The purpose of this study is to evaluate the effectiveness of the MicroCutter Stapler in a real world setting in thoracic surgery procedures.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
16-006305
NCT ID:
NCT02816671
Sponsor Protocol Number:
CP-2016-01

Ultrasound Image Quality of the Brachial Plexus Before and After Shoulder Arthroscopy

Rochester, MN

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Ultrasound Image Quality of the Brachial Plexus Before and After Shoulder Arthroscopy

Study type:
Observational
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

About this study

The objective of the study is to determine if there is a difference in ultrasound image quality of the interscalene block anatomy, at point of care, pre- versus post-operatively in a cohort of patients undergoing shoulder arthroscopy who routinely receive blockade of the brachial plexus for postoperative analgesia.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
18-004131
NCT ID:
NCT03657173
Sponsor Protocol Number:
18-004131

A Study Investigating Long-term Treatment With Spesolimab In People With A Skin Disease Called Hidradenitis Suppurativa Who Completed A Previous Clinical Trial

Rochester, MN

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A Study Investigating Long-term Treatment With Spesolimab In People With A Skin Disease Called Hidradenitis Suppurativa Who Completed A Previous Clinical Trial

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
2
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

The primary objective of this trial is to assess the long-term safety of spesolimab in patients with HS who have completed the 1368-0052 PoCC trial and are qualified for entry into this trial. The secondary objectives are to evaluate effectiveness at a lower dose than tested in PoCC trial.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
21-009574
NCT ID:
NCT04876391
Sponsor Protocol Number:
1368-0067

Lidocaine as an Endotracheal Tube (ETT) Cuff Media

Rochester, MN

See Details

Lidocaine as an Endotracheal Tube (ETT) Cuff Media

Study type:
Interventional
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
2
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

About this study

Researchers will compare the effects of lidocaine versus air, as a way to fill the breathing tube cuff which is gently inflated to hold in place the trachea (airway) during surgery. Air is the traditional method used to inflate the breathing tube cuff. Researchers wish to find if lidocaine works better than air to facilitate tolerance to the breathing tube (decreased coughing, sore throat, hoarseness). They also want to learn more about its effectiveness for this particular surgical intervention.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location	Status	Contact
Rochester, MN	Closed for enrollment	View complete study & contact information

Print study details

Site IRB:
16-000621
NCT ID:
NCT03343080
Sponsor Protocol Number:
16-000621

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Search Results 1221-1230 of 2056 for surgery

Does Surgical Approach Affect Patient Satisfaction and Joint Awareness Following Total Hip Arthroplasty?

Revision Knee Replacement for Flexion Instabiity

Leveraging AI/ML Algorithms On Digital Pathology And Ex-Vivo Confocal Microscopy Imaging For Extramammary Paget’s Disease

Post-Surgical Based Efforts to Reduce Preventable Readmissions and Optimize Length of Stay

Study Of Intralesional Cemiplimab In Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

A Study of the Effects of Synovial (Joint Lubricating) Fluid on the Development of Osteoarthritis

A Study To Evaluate The Staple Line Control Of Bleeding For MicroCutter Assisted Thoracic Surgery

Ultrasound Image Quality of the Brachial Plexus Before and After Shoulder Arthroscopy

A Study Investigating Long-term Treatment With Spesolimab In People With A Skin Disease Called Hidradenitis Suppurativa Who Completed A Previous Clinical Trial

Lidocaine as an Endotracheal Tube (ETT) Cuff Media

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