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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 81 for epilepsy

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  1. A Study to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection Using Intraoperative Brain Microdialysis

    Rochester, MN

  2. A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy, with an Open-Label Extension

    Jacksonville, FL, Rochester, MN

  3. A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrome

    Rochester, MN

  4. Study of Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy

    Rochester, MN

  5. A Study to assess the Safety of NRL-1 for the Treatment of People with Epilepsy

    Rochester, MN

  6. Pilot Study to Evaluate MR-guided Laser Ablation of Focal Lesions in Patients with Medically Refractory Partial Epilepsy

    Jacksonville, FL, Rochester, MN

  7. A Study to Characterize the Performance of Brain Laser (LITT) Ablation for Treating Epilepsy that is Resistant to Medical Therapy

    Jacksonville, FL

  8. A Study to Test the Safety and Effectiveness of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects with Drug-resistant Epilepsy

    Rochester, MN

  9. A Study to Evaluate fMRI of Active Deep Brain Stimulation in Epilepsy

    Jacksonville, FL

  10. Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy

    Scottsdale/Phoenix, AZ

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