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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

Study phase

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 261-270 of 847 for cardiovascular

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  1. Randomized Placebo-controlled Trial of FCM as Treatment for Heart Failure With Iron Deficiency

    Jacksonville, FL

  2. An Extension Study to QTI571A2301 to Evaluate the Long-Term Safety, Tolerability and Effectiveness of Imatinib in Severe Pulmonary Arterial Hypertension

    Rochester, MN

  3. A Study to Evaluate Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having Heart Failure with Preserved Ejection Fraction

    Rochester, MN

  4. Use of Remote Monitoring to Improve Physician Monitoring, Patient Satisfaction, and Predict Readmissions Following Cardiac Surgery

    Rochester, MN

  5. Clinical Use of the Impella RP System

    Rochester, MN

  6. A Study of Ubenimex in Patients with Pulmonary Arterial Hypertension

    Rochester, MN

  7. Safety of Ataciguat in Patients with Moderate Calcific Aortic Valve Stenosis

    Rochester, MN

  8. A Study of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Stage II Palliation of Hypoplastic Left Heart Syndrome

    Rochester, MN

  9. A Study Comparing Air versus Blood with Saline as Contrast Shading for Echocardiographic Imaging of the Right Heart and Shunts

    Rochester, MN

  10. Evaluation of the Phased Radio Frequency Ablation System

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