Diet, Vascular Health and the Gut Microbiome in Heart Failure


About this study

Heart failure with reduced ejection (HFrEF) is a major health concern. HFrEF is associated with significant endothelial dysfunction (ED). The purpose of this study is to compare the effects of a Western diet (WD) to a high-carbohydrate, high-fiber diet (HCHF) on endothelial function in patients with HFrEF. the study will look at the distribution of intestinal microbe communities after following the diets as well as explore relationships between gut health and ED in patients with HFrEF.

We propose to address this important gap in the literature with a study design that is responsive to needs in the area of healthcare delivery and disease management in this population of patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Diagnosed with chronic, compensated congestive heart failure [New York Heart Association (NYHA) Class II-III] 
  • Between the ages of 40-99 years

Exclusion Criteria:

  • Unstable angina
  • Recent myocardial infarction (<4 weeks)
  • Decompensated heart failure
  • NYHA functional class IV
  • Complex ventricular arrhythmias at rest
  • Symptomatic severe aortic stenosis
  • Acute pulmonary embolism
  • Acute myocarditis
  • Recent hospitalization in the past 6 weeks
  • Non-use of ßblockers/angiotensin converting enzyme inhibitors

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Reza Arsanjani, M.D.

Closed for enrollment

More information


Publications are currently not available

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