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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 63 for alzheimer

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  1. A Study of Crenezumab in Participants With Mild to Moderate Alzheimer Disease

    Scottsdale/Phoenix, AZ

  2. Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

    Rochester, MN

  3. A Long Term Study of Molecular and Structural Imaging in Atypical Alzheimer's Disease

    Rochester, MN

  4. A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies

    Rochester, MN, Jacksonville, FL

  5. Exercise in Asymptomatic Pre-Alzheimer's Disease Pilot Study

    Jacksonville, FL

  6. A Study to Evaluate the Safety and Effectiveness of Gantenerumab in Participants With Early Alzheimer's Disease (AD)

    Scottsdale/Phoenix, AZ

  7. 221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease

    Jacksonville, FL

  8. An Efficacy and Safety Trial of MK-8931 in Mild to Moderate Alzheimer's Disease (P07738)

    Scottsdale/Phoenix, AZ

  9. Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo

    Jacksonville, FL

  10. An Extension Study of ABBV-8E12 in Early Alzheimer's Disease (AD)

    Jacksonville, FL

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