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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 88 for Surgery

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  1. A Study to Evaluate the Safety and Immunological Effect of Pembrolizumab in Resectable or Borderline Resectable Pancreatic Cancer

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  2. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

    Jacksonville, FL, Rochester, MN

  3. A Study to Assess the GORE® EXCLUDER® Conformable Endoprosthesis for the Treatment of Abdominal Aortic Aneurysms

    Rochester, MN

  4. Trial of Multi-epitope HER2 Peptide Vaccine in Patients with HER2-expressing DCIS

    Jacksonville, FL, Rochester, MN

  5. Stem Cell Coated Fistula Plug in Patients With Crohn's RVF

    Rochester, MN, Rochester, MN

  6. A Study to Compare Somatostatin Analogues with Perioperative Antibiotics versus Prolonged Antibiotics

    Rochester, MN

  7. A Study to Evaluate Wellness Coaching for Caregivers of Thoracic Transplant Candidates

    Rochester, MN

  8. Topical Tranexamic Acid in Complex Cardiac Surgery: Does it Reduce Transfusion Need?

    Rochester, MN

  9. A Study to Determine the Effects of Blocking the Receptors of GLP-1 on Appetite after Bariatric Surgery

    Rochester, MN

  10. Assessing the Accuracy of Tumor Biopsies After Chemotherapy to Determine if Patients Can Avoid Breast Surgery

    Rochester, MN

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