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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 297 for General Internal Medicine

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  • Study status: Open/Status Unknown
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  1. Sponge and Eosinophil Peroxidase (EPO) Staining

    Rochester, MN

  2. Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

    Rochester, MN

  3. A Study of Quality of Life and Pain Control Before and After Endovascular Renal Denervation in Individuals with Refractory Kidney Pain

    Rochester, MN

  4. A Study for Sources of Pulmonary Congestion Associated with Heart Failure

    Rochester, MN

  5. Transforming Non-Invasive Liver Disease Detection by Magnetic Resonance Elastography

    Rochester, MN

  6. In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells

    Rochester, MN

  7. Phase II Study of EUS-guided Verteporfin PDT in Solid Pancreatic Tumors

    Rochester, MN

  8. A Study to Evaluate Injectafer® as Treatment for Heart Failure with Iron Deficiency

    Rochester, MN

  9. P1101 in Treating Patients With Early Myelofibrosis

    Scottsdale/Phoenix, AZ

  10. A Global Study to Assess the Effects of MEDI4736, Given as Monotherapy or in Combination With Tremelimumab Determined by PD-L1 Expression Versus Standard of Care in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer

    Scottsdale/Phoenix, AZ

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