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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 78 for Endocrinology

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  • Study status: Open/Status Unknown
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  1. Shared Decision Making in the Treatment of Obesity Through the Development of an Encounter Tool

    Rochester, MN

  2. A Study to Evaluate the Effect of Metformin on Brain Function in Insulin-resistant Elderly People

    Rochester, MN

  3. A Study to Evaluate Molecular Mechanisms of Exercise Benefits in Insulin Resistant People

    Rochester, MN

  4. Cisplatin and Etoposide or Temozolomide and Capecitabine in Treating Patients With Neuroendocrine Carcinoma of the Gastrointestinal Tract or Pancreas That Is Metastatic or Cannot Be Removed by Surgery

    Rochester, MN

  5. A Study to Evaluate the Impact of Nutrition Education and Access to Nutritious Foods on Diabetes Control

    Mankato, MN

  6. A Study of LOXO-292 in Patients with Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer

    Scottsdale/Phoenix, AZ, Jacksonville, FL, Rochester, MN

  7. Effect of Fasting, Endogenous GLP-1 Secretion on B-cell Response to Intravenous Glucose

    Rochester, MN

  8. A Clinical Study Investigating the Safety, Tolerability, PK and PD of PCO371 in Patients With Hypoparathyroidism

    Rochester, MN

  9. A Study to Assess Effectiveness and Safety of Octreotide Subcutaneous Depot in Patients With Acromegaly

    Rochester, MN

  10. A Study to Evaluate Individualized Lifestyle Intervention for Obesity Management Based on Obesity Phenotypes

    Rochester, MN

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