A Study to Examine the Molecular Mechanisms of Acute Effects of Resistance Exercise


About this study

The purpose of this study is to seek and identify the mechanistic underpinnings of the effects of resistance exercise (RE) on insulin sensitivity.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 18-55 years old.
  • BMI 21.0 – 32.0 kg/m^2.

Exclusion Criteria:

  • BMI > 32.0 kg/m^2.
  • For the 20 participants who are involved in training - participation in structured exercise (>2 times per week for 30 minutes or longer).
  • For the 10 participants in the aerobic arm - do not participate in structured exercise > 5 times per week.
  • For all participants - cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease, orthopedic problems that would keep them from being able to perform leg extensions; medications that are known to have an impact on mitochondrial function: 
    • Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist), smoking, pregnancy. 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

K Nair, M.D., Ph.D.

Open for enrollment

Contact information:

Frederick de Ruiter B.S.

(507) 255-8932


More information


Publications are currently not available

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