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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 1-10 of 98 for Orthopedic Surgery

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  • Study status: Open/Status Unknown
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  1. Direct Anterior vs. Anterolateral Approach for Hip Arthroplasty After Femoral Neck Fracture in the Senior Population

    Rochester, MN

  2. A Study of Clinical Outcomes of Ultrasound-guided Carpal Tunnel Release Performed in a Procedural Room Setting

    Albert Lea, MN

  3. 4DCT Imaging for Improved Diagnosis and Treatment of Wrist Ligament Injuries

    Rochester, MN

  4. A Study Comparing the Outcome of a Large-Diameter versus Small-Diameter Glenosphere (Shoulder/Arm Ball-Joint) in Primary Reverse Shoulder Arthroplasty

    Rochester, MN

  5. A Study to Evaluate Low-Intensity Blood Flow Restriction Training to Improve Post-Operative Outcomes for ACL Reconstruction

    Scottsdale/Phoenix, AZ

  6. A Blanket Protocol to Study Oral Regorafenib in Patients with Selected Sarcoma Subtypes

    Jacksonville, FL, Rochester, MN

  7. Study Comparing NOVOCART 3D and Microfracture Surgery for Treatment of Articular Knee Cartilage

    Rochester, MN

  8. A Study of Anterior Cruciate Ligament Injury and Rehabilitation

    Rochester, MN, Minneapolis, MN

  9. A Study of Lofexidine for Rapid Opioid Tapering in Adults

    Rochester, MN

  10. A Study of Performance of a New Investigational Prosthesis Design and Explore How Mimicking the Human Ankle May Enhance Maneuverability of Walking

    Rochester, MN

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