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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 21-30 of 67 for Nephrology and Hypertension

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  • Study status: Open/Status Unknown
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  1. A Study to Compare ShockPulse-SE vs. Trilogy Lithotripters for Removal of Large Kidney Stones

    Scottsdale/Phoenix, AZ

  2. A Study to Evaluate the Safety and Effectiveness of Clazakizumab for the Treatment of Chronic Active Antibody-Mediated Rejection in Kidney Transplant Recipients

    Scottsdale/Phoenix, AZ, Rochester, MN

  3. A Study to Determine Effectiveness and Safety of Ultrasound Shockwave Therapy for Post-Stenotic Microvascular Modeling

    Rochester, MN

  4. Physiologic Effects of Sleep Restriction

    Rochester, MN

  5. Sleep Restriction and Obesity

    Rochester, MN

  6. A Safety and Efficacy Study of FCR001 vs Standard of Care in de Novo Living Donor Kidney Transplantation

    Rochester, MN, Scottsdale/Phoenix, AZ

  7. Feasibility and Safety of Allogeneic Adipose Mesenchymal Stem Cells (aMSCs) Delivery Into Kidney Allografts Procured from Deceased Donors with High Kidney Donor Profile Index (KDPI)

    Jacksonville, FL

  8. Open-label Trial of Daratumumab in Treatment of PGNIMD and C3 GN

    Rochester, MN, Jacksonville, FL

  9. A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety

    Jacksonville, FL

  10. A Study to Evaluate the Effectiveness and Safety Study of Imlifidase in Treatment of Antibody-Mediated Rejection in Kidney Transplant Patients

    Rochester, MN

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