A Study to Evaluate Colorectal Polyps with Dietary Inflammation During Colonoscopy


About this study

Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States (1). Colorectal cancer arises from colonic polyps. The major types of polyps associated with colorectal cancer development are adenomatous (tubular which is most common and other types are villous and tubulovillous) and serrated (hyperplastic, sessile or traditional) polyps with varying degrees of dysplasia (2). Hyperplastic polyps are common but they have a low malignancy potential (3). There is evidence that colonic inflammation plays a major role in colon polyp and colorectal cancer development. For example, inflammatory bowel disease is a major predisposing factor for colorectal cancer occurrence, implicating inflammation in the development of colorectal cancer (4). In addition,  obesity, a chronic inflammatory state, is associated with increased colorectal cancer risk (5). However, the use of anti-inflammatory agents in the prevention of colorectal cancer is controversial, although there is some suggestion that its use may lower colorectal cancer risk (6,7). Diet may affect cytokine levels and inflammation (8). Diet rich in trans-fat and sugar has been shown to increase pro-inflammatory cytokines IL-6 and TNFα (9, 10) and the Mediterranean Diet has been shown to decrease inflammatory cytokines (11) and decrease the risk of colon cancer in an UK study (12). Recently, the EDII was developed and validated to assess inflammatory potential of diet based on the Food Frequency Questionnaire (FFQ) (13).  Here we propose to investigate the association between diet-derived inflammation, as measured by the EDII, risk of colon polyps during screening colonoscopy and colorectal cancer development.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Men and women, aged 50 - 75 years old, inclusive.
  • Colonoscopy screening at Mayo Clinic/Jacksonville, FL.
  • No history of colonic polyps or colorectal cancer.

Exclusion Criteria:

  • Participants who reported personal history of cancer except nonmelanoma skin cancer or family history of colon cancer.
  • Participants who had implausibly high or low values for total calories intake (< 600 or > 3500 kcal/d for women and < 800 or > 4200kcal/d for men).
  • Prior surgery to the colon.
  • Known inflammatory bowel disease.
  • History of mechanical obstruction of the GI tract.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Bhaumik Brahmbhatt, M.B.B.S.

Open for enrollment

Contact information:

Alfred Nelson M.B.B.S.

(904) 953-7382


More information


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Additional contact information

Cancer-related trials contact form

Phone: 855-776-0015 (toll-free)

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