David G. Lott, M.D.

The purpose of this study is to establish a tissue and fluid biorepository for use in future studies of idiopathic subglottic stenosis (iSGS), also to create an iSGS knowledge base of clinical data to complement findings for future studies.

The purpose of this study is to assess the safety and effectiveness of APrevent® VOIS Implants for the treatment of patients with Unilateral Vocal Fold Paralysis (UVFP). In total 30 evaluable patients are planned to be enrolled.

The purpose of this study is to develop the procedures for the growth of specific cells and tissues needed for reconstruction surgeries of the head and neck using the waste tissues of other surgeries.

The purpose of this study is to evaluate the effiectiveness and tolerability of INO-3107 in subjects with HPV6 and/or HPV-11- associated RRP, who have previously received INO-3107.

The purpose of this proposed study is to obtain safety and efficacy data on human laryngeal allograft transplantation in an effort to safely use these procedures as a viable reconstructive option for patients with severe laryngeal or laryngotracheal incompetence.

The purpose of this study is to evaluate the effectiveness, safety, tolerability and immunogenicity (ability to produce immune response) of INO-3107 in participants with HPV-6 and/or HPV-11 associated recurrent respiratory papillomatosis (RRP). 

The goal of this research study is to evaluate the impact of surgical interventions on circulating biomarker dynamics and establish their prognostic role in carcinoma of the head and neck treated with intended curative surgery.

The purpose of this study is to describe past evidence of effectiveness of endoscopic balloon dilation in treating glottic stenosis and bilateral vocal fold immobility since July 2011 at Mayo Clinic, Arizona.

The purpose of this study is to evaluate the quality of life before and after functional laryngectomy for patients with end-stage dysphagia.

The purpose of this study is to measure physiology and anatomy related to various phonatory tasks while playing a musical instrument and compare with normal phonation. 

In patients with gastroesophageal reflux and/or laryngopharyngeal reflux with cricopharyngeal hypertrophy or Zenker's diverticulum, does cricopharyngeal myotomy increase the amount of laryngopharyngeal reflux?

In-depth qualitative interviews will be performed to explore beliefs of laryngotracheal transplant candidates, their caregivers, and clinicians about their perceptions and experience of the laryngotracheal transplantation process. In addition, we will explore the quality of life of patients with a laryngectomy.

The purpose of this study is to compare the most commonly used treatment alternatives for idiopathic subglottic stenosis and to assess the differences in how each affects breathing, voice, swallowing, and quality-of-life.