SUMMARY
David G. Lott, M.D., an otolaryngologist, is an expert in regenerative medicine and otolaryngology (ENT)/head and neck surgery. He is dedicated to conducting research to improve treatment options for disorders of the larynx and trachea, including groundbreaking transplants.
Dr. Lott's cutting-edge work includes:
- Bioengineering of laryngeal and tracheal tissues.
- Laryngeal transplantation techniques and immunotherapy.
- Laryngeal cancer treatment.
- Functional outcomes of laryngeal surgical procedures.
In 2024, Dr. Lott led a team at Mayo Clinic that performed the world's first laryngeal transplant for a person with active cancer. This achievement marked a groundbreaking advance in total larynx transplant.
Dr. Lott is the principal investigator of the Head and Neck Regenerative Medicine Laboratory. The lab develops products and procedures to regenerate head and neck structures using all the elements of regenerative medicine, including scaffold generation, stem cell differentiation and acellular therapeutics. Email Dr. Lott's Lab for more information about the lab's initiatives.
Dr. Lott also is the founder and medical director of the Larynx and Trachea Transplant Program. The program aims to restore a better quality of life for people with severe laryngeal dysfunction or laryngectomy.
Focus areas
- Laryngeal transplantation.
- Tissue engineering in laryngeal and airway reconstruction.
- Idiopathic subglottic stenosis.
- Voice and swallowing outcomes in laryngeal cancer resection.
Significance to patient care
Dr. Lott's research efforts use regenerative medicine and transplantation to bring back function of the larynx and trachea in the throat. This allows patients to regain or preserve the ability to breathe, swallow and speak.
Professional highlights
- Mayo Clinic:
- Chair, Department of Otolaryngology-Head & Neck Surgery/Audiology, Mayo Clinic in Arizona, 2023-present.
- Associate director, Center for Regenerative Biotherapeutics, Mayo Clinic in Arizona, 2017-2024.
- Teacher of the Year, Mayo Clinic School of Graduate Medical Education, 2023.
- Distinguished Clinician, 2021.
- Top Provider Recognition Award, 2020.
- Featured article, "Giving Them Their Voice," Mayo Clinic Magazine, 2016.
- Transform the Practice Award, 2016.
- Top Voice Doctors in America, Billboard Magazine, 2015.