A Study of Treatment Alternatives for Idiopathic Subglottic Stenosis


About this study

The purpose of this study is to compare the most commonly used treatment alternatives for idiopathic subglottic stenosis and to assess the differences in how each affects breathing, voice, swallowing, and quality-of-life.


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Greater than 18 years of age
  • The lesion must involve the subglottis

Exclusion Criteria

  • Less than 18 years of age
  • Patients without capacity to consent for themselves
  • History of significant laryngotracheal traumatic injury
  • History of endotracheal intubation or tracheotomy within 2 years of presentation
  • Major anterior neck surgery
  • History of neck irradiation
  • History of caustic or thermal injuries to the laryngotracheal complex
  • History of a clinically diagnosed vasculitis or collage vascular disease
  • Positive antinuclear cytoplasmic antibody titers

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

David Lott, M.D.

Closed for enrollment

More information


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