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The purpose of this study is to investigate the facilitators and barriers of adults with a history of cocaine use disorder (CocUD) in sustained remission to participating in a Phase I gene transfer study aimed at reducing the rate of cocaine relapse.
The purpose of this study is to compare the effectiveness of combination therapy with antidepressants (AD), fear avoidance rehabilitation (EFAR) AD+EFAR vs. each treatment alone to improve pain, self-reported function, depression, and anxiety in patients with chronic low back pain and high negative affect.
The primary purpose of this study is to identify patient characteristics that are associated with unintended prolonged opioid use (UPUO).
The purpose of this study is to investigate the effects of buprenorphine on hyperalgesia (HP) perception in adults undergoing treatment for opioid use disorder (OUD).
The purpose of this study is to see if an experimental agent, when given to subjects who wish to abstain from cocaine, will decrease their craving for cocaine and prevent them from relapsing and returning to cocaine use. This experimental agent is called AAV8-hCocH; and it is a gene modified viral vector. We want to determine the safety of its use in adults who have a cocaine use disorder in sustained remission.
The purpose of this study is to assess the effects of lofexidine on opioid tapering in adults undergoing opioid tapering prior to elective lumbar spine surgery.
The purpose of this study is to determine if a brief educational intervention about the connections between smoking and chronic pain will promote the participation in a smoking abstinence therapy program among smokers seeking treatment for chronic pain.
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