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  • Outcomes of Descemet Membrane Endothelial Keratoplasty Rochester, Minn.

    The goal of this study is to determine optical and visual function through 5 years after Descemet membrane endothelial keratoplasty (DMEK). The study will also determine graft health (corneal endothelial cell loss) and survival through 5 years after DMEK, and factors associated with these outcomes, as well as assess the relationship between optical and anatomical corneal rehabilitation after DMEK.

  • Visual Function in Fuchs Endothelial Corneal Dystrophy Rochester, Minn.

    The purpose of this study is to determine visual function in patients with Fuchs Endothelial Corneal Dystrophy (FECD) to understand when in the course of disease patients are affected by compromised vision.

Closed for Enrollment

  • Corneal Backscatter in Fuchs Endothelial Dystrophy Rochester, Minn.

    The purpose of this study is to determine how corneal transparency is affected in Fuchs dystrophy, and if a measure of corneal transparency (haze) can help grade the severity of the disease.

  • Diurnal Variation in Corneas with Fuchs Endothelial Dystrophy Rochester, Minn.

    The purpose of this study is to determine changes in corneal thickness and backscatter after first morning eye-opening across a range of fuchs endothelial dystrophy severity, and in healthy corneas. Corneal measurements will be made with a Scheimpflug camera and associated changes in visual acuity and glare (forward scatter) will be determined.

  • Scheimpflug Analysis of Normal Corneas Rochester, Minn.

    The purpose of this study is to establish central and peripheral corneal thickness across a broad age range of subjects with normal corneas.  Determine normal light scattering properties from the cornea.  Establish trends in the curvature of the anterior and posterior surfaces of the cornea with age.

  • Vision-Related Quality of Life in Fuchs Endothelial Corneal Dystrophy Rochester, Minn.

    The goal of this study is to understand when in the course of disease vision-related quality of life becomes impaired, and to determine associations between quality of life and visual and optical factors in the disease.

  • Visual Function and Corneal Health Status in Fuchs Dystrophy Rochester, Minn.

    The purpose of this study is to test how valid and reliable the new V-FUCHS questionnaire is across a spectrum of Fuchs dystrophy patients.

  • Visual Function and Corneal Health Status in Fuchs Dystrophy II Rochester, Minn.

    The purpose of this study is to compare patient-reported visual disability before and after endothelial keratoplasty in patients with Fuchs endothelial corneal dystrophy by comparing scores of the previously designed and validated Visual Function and Corneal Health Status (V-FUCHS) questionnaire. Patient-reported disability will be related to the optical properties of the cornea measured by non-contact imaging methods.

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