A Study of Daytime Changes in Corneas with Fuchs Dystrophy


About this study

The purpose of this study is to determine changes in corneal thickness and backscatter after first morning eye-opening across a range of fuchs endothelial dystrophy severity, and in healthy corneas. Corneal measurements will be made with a Scheimpflug camera and associated changes in visual acuity and glare (forward scatter) will be determined.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

Inclusion Criteria

  • Presence of central or paracentral corneal guttae
  • Any age, with expected range of 40-90 years
  • Any sex or race
  • Some normal subjects will be recruited, with normal corneas
    • Absence of central or paracentral corneal guttae
    • Above 50 years of age to match the predominant age of onset of FECD
    • Any sex or race

Exclusion Criteria 

  • Corneal disease (except Fuchs dystrophy in the Fuchs dystrophy group)
  • Previous occular surgery or refractive laser treatment
  • Current contact lens wear
  • Use of topical medications (except artificial tears) or systemic medications known to affect the cornea
  • Glaucoma or occular hypertension
  • Systemic diseases known to affect the cornea, e.g. diabetes

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Sanjay Patel, M.D.

Closed for enrollment

Contact information:

Emily Treichel



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


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