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A Study to Compare HF10 Therapy Combined With CMM to CMM Alone in the Treatment of Non-Surgical Refractory Back Pain
Scottsdale/Phoenix, AZ
The purpose of this study is to document the safety, clinical effectiveness and cost-effectiveness of high-frequency SCS at 10 kHz (HF10™ Therapy) delivered through the Senza system in subjects with chronic refractory back pain (with or without leg pain) who are not considered candidates for spine surgery. This study is a multi-center, prospective, randomized study to compare the two treatment groups.
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A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of a Single Injection of Rexlemestrocel-L Alone or Combined With Hyaluronic Acid (HA) in Subjects With Chronic Low Back Pain
Rochester, MN
This is a prospective, multicenter, randomized, double-blind, placebo-controlled Phase 3 study designed to evaluate the safety and efficacy of Mesoblast's rexlemestrocel-L alone or combined with hyaluronic acid (HA) in subjects with chronic low back pain (> 6 months) associated with moderate radiographic degenerative changes of a disc
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A Study to Evaluate Patient Experience Comparing Tonic vs. Burst Spinal Card Stimulation for Chronic Pain
Jacksonville, FL
The purpose of this study is to evaluate if subjects who have already experienced tonic spinal cord stimulation would have a better pain relief status with burst spinal cord stimulation
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A Study to Evaluate the Effectiveness of Tuina in Managing Chronic Low Back Pain
Rochester, MN
This research study is designed to evaluate the efficacy of Tuina therapy (Chinese massage therapy) compared to physiotherapy for low back pain.
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A Study to Utilize a Tonal Exercise System to Improve Low Back Pain (LBP) Treatment Outcomes
Rochester, MN; Minneapolis, MN
This study will assess the effect of incorporating a tonal exercise device into clinical and chiropractic care for lower back pain.
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A Study to Compare HF10 Therapy Combined with Conventional Medical Management (CMM) to CMM Alone in the Treatment of Non-Surgical Refractory Back Pain
Rochester, MN
The purpose of this study is to document the safety, clinical effectiveness and cost-effectiveness of high-frequency HF10™ Therapy, delivered through the Senza system, in subjects with chronic refractory back pain (with or without leg pain) who are not considered candidates for spine surgery. This study is a multi-center, prospective, randomized study to compare the two treatment groups.
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A Study of Lofexidine for Rapid Opioid Tapering in Adults
Rochester, MN
The purpose of this study is to assess the effects of lofexidine on opioid tapering in adults undergoing opioid tapering prior to elective lumbar spine surgery.
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Shared Decision Making in Patients with Neck and Back Pain – Options in Neck and Back Pain Management
Rochester, MN
The purpose of this study is to develop, in close collaboration with stakeholders and the Mayo Clinic Spine Center, an evidence-based decision aid for the management of acute and sub-acute cervical and lumbar radiculopathies – “Options in Back Pain Management.”
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Dorsal spinal cord stimulation vs medical management for the treatment of low back pain
Rochester, MN
The purpose of this study is to evaluate the effectiveness of BurstDRTM spinal cord stimulation, compared with comprehensive medical management, in improving pain and back-related physical function in patients suffering with chronic, refractory axial low back pain with a neuropathic component, who have not had lumbar spine surgery and for whom surgery is not an option.
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A Study Comparing Effectiveness and Safety of SPIRA-A Anterior Lumbar Interbody Fusion Device to PEEK Anterior Lumbar Interbody Fusion Cage with rhBMP-2 in Instrumented Lumbar Fusions
Rochester, MN
The purpose of this study is to evaluate if SPIRA-A Anterior Lumbar Interbody Fusion Device is equivalent in effectiveness and safety to PEEK Anterior Lumbar Interbody Fusion Cage with rhBMP-2 when used in instrumented lumbar fusions.
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Study of Lumbar Discectomy with Additional Implantation of an Annular Closure Device in Patients with Large Postsurgical Annular Defects
Jacksonville, FL
The purpose of this study is to confirm the efficacy of the Barricaid® when used as an adjunct to a primary lumbar limited discectomy, to limited discectomy alone, with regard to preventing reherniation and the recurrence of pain or dysfunction in a US population.
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A Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries
Rochester, MN
The primary purpose of this study is to compare postsurgical opioid consumption through 72 hours postsurgery in patients receiving local infiltration analgesia (LIA) with EXPAREL and bupivacaine HCl (EXPAREL group) with that of patients receiving standard of care (SOC) (control group) in adult subjects undergoing posterior lumbar spine surgeries where both groups are receiving a multimodal pain regimen.
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Systems That May Produce Central Sensitization Syndrome of LBP
Rochester, MN
The purpose of this study is to investigate the effects of Central Sensitization and Glymphatic flow in connection with chronic low back pain. Data will be assessed to determine the effect of these characteristics on the symptoms of low back pain. Future work from this pilot study will include a clinical trial to assess how these aspects can be altered to improve the outcomes of chronic low back pain.
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A Study of the Effectiveness of EXPAREL for Pain Control in Adult Subjects Undergoing Open Lumbar Spinal Fusion Surgery
Rochester, MN
The purpose of this study is to compare postsurgical pain control following local infiltration analgesia and bupivacaine HCl with EXPAREL, versus without EXPAREL, in adult subjects undergoing open lumbar spinal fusion surgery. The study will also compare additional effectiveness, safety, and health economic outcomes.
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Study Evaluating the Side Effects of Bone Marrow-Derived Stem Cells When Injected Into the Facet Joints for the Treatment of Painful Arthropathies
Jacksonville, FL
The purpose of this study is to determine the safety and feasibility of allogeneic, culture-expanded BM-MSCs in subjects with painful facet joint arthropathy.