Systems That May Produce Central Sensitization Syndrome of LBP


About this study

The purpose of this study is to investigate the effects of Central Sensitization and Glymphatic flow in connection with chronic low back pain.  Data will be assessed to determine the effect of these characteristics on the symptoms of low back pain.  Future work from this pilot study will include a clinical trial to assess how these aspects can be altered to improve the outcomes of chronic low back pain.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Participants must be classified with a diagnosis of chronic low back pain.
  • Participants must be able to speak, listen, read, and understand sentences written in English.

Exclusion Criteria: 

  • Participants will be excluded who:
    • display more than two risk factors for coronary artery disease (high blood pressure, high blood cholesterol level (LDL), family history (a close relative with heart disease), diabetes mellitus, chronic kidney disease;
    • have a history of falls, osteoporosis, osteoarthritis, or orthopedic or neurological conditions (i.e., stroke);
    • take medications that cause dizziness or slow movement;
    • smoke; or
    • have a body mass-to-height squared ratio greater than 30kg/m^2 or less than 18.4kg/m^2, blood pressure greater than 140/90 mmHg, or a history of heart conditions.
  • Individuals with progressive cognitive, neurologic disorders, cancer treatment, chronic heart failure, or unstable medical conditions will also be excluded.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Nathan Schilaty, Ph.D.

Closed for enrollment

Contact information:

Nathan Schilaty Ph.D.

(507) 538-7047

More information


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