Displaying 23 studies

  • A Study to Evaluate Aqueous Humor Dynamic Components Rochester, MN

    The purpose of this study is to identify reasons for variations in eye pressure response to glaucoma drugs between individuals. 

  • A Study to Evaluate the Use of Micropulse Trans-Scleral Cyclophotocoagulation Laser (MP-TSCPC) for Glaucoma Patients Jacksonville, FL

    The purpose of this study is to evaluate the clinical outcomes of the Micropulse Trans-Scleral Cyclophotocoagulation Laser (MPTSCPC) after 1 day, 1 week,1 month, 3 months, 6 months and one year of follow-up. Its primary objective is to conduct a prospective observational study on the efficacy of using MP-TSCPC to treat glaucoma patients.

  • Mechanisms of Eye Pressure Changes Rochester, MN

    To determine the reasons why eye pressure varies over time and between individuals. For patients with glaucoma, we are also trying to determine the mechanisms that control changes in eye pressure with the disease and standard treatments.

  • A Study Using Ultrasound Surface Wave Elastography to Measure Tissue Thickness and Elasticity in Eyes with Glaucoma Rochester, MN

    The purpose of this study is to use Ultrasound surface wave elastography to measure and compare the tissue thickness and elasticity in normal eyes and eyes with glaucoma. The goal is to understand the association between tissue characteristics and glaucoma.

  • Risk Factors for Exfoliation Syndrome, Exfoliation Glaucoma and Primary Open Angle Glaucoma Rochester, MN

    We are doing this research study to find out the genetic and environmental factors that contribute to glaucoma (high pressure in the eye), which can cause vision loss and blindness if untreated. Exfoliation syndrome is a common condition that can lead to exfoliation glaucoma. The most common form of glaucoma is called primary open angle glaucoma. Identifying the factors that lead to exfoliation syndrome and glaucoma may help us to develop future tests and treatments for these conditions.

  • Teleophthalmology in the Management of Glaucoma Rochester, MN

    The purpose of this study is to determine accuracy of glaucoma progression assessment (non-progression, possible progression, or definite progression) in glaucoma patients based on images only by determining agreement between each classification from non-visit data and in-person evaluation.

  • Glaucoma Outcomes Survey La Crosse, WI

    The purpose of this research study is to determine how useful a questionnaire, the Glaucoma Outcomes Survey (GOS), is as a tool for measuring patient quality of life after undergoing minimally invasive glaucoma surgery combined with cataract surgery.


  • A Study to Evaluate Variations in Episcleral Venous Pressure Rochester, MN

    The purpose of this study is to investigate the daily variations in episcleral venous pressure (EVP), the relationship between EVP and blood pressure (BP) variations, and the effect of anti-hypertension medications on these variations. The effect of blood volume increase after water drinking on BP, intraocular pressure (IOP), and EVP will also be assessed.

  • A Study to Compare XEN-45 Gel Stent Versus Trabeculectomy in Glaucoma Jacksonville, FL

    The purpose of this study is to compare the effectiveness and safety of XEN to trabeculectomy in subjects with open angle glaucoma refractory to topical medical therapy.

  • Study of Netarsudil Ophthalmic Solution in Subjects With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) Rochester, MN

    To evaluate the effect on trabecular outflow facility of Netarsudil ophthalmic solution 0.02% compared to placebo

  • Effect of Topical Phenylephrine 2.5% on EVP in Normal Human Eyes Rochester, MN

    Phenylephrine hydrochloride ophthalmic solution is an alpha-1 adrenergic receptor agonist commonly used topically for dilation prior to ocular fundus examination. In the eye, phenylephrine acts locally as a potent vasoconstrictor and mydriatic by constricting ophthalmic blood vessels and the radial dilator muscle of the iris. Episcleral venous pressure (EVP) is a determinant of intraocular pressure (IOP) and can be measured non-invasively by venomanometry. Since phenylephrine is a vasoconstrictor, it may affect episcleral venous tone, but the effect on EVP is unknown. Understanding the physiology of episcleral veins helps us in better understanding of pathophysiology of glaucoma.

  • A Study of Changes that Occur with Glaucoma Therapies and Provocative Tests Rochester, MN

    The purpose of this study is to understand the aqueous humor dynamics changes that occur with glaucoma therapies and provocative tests. 

  • Early Detection of Glaucomatous Optic Neuropathy Rochester, MN

    The goal of this study is to determine if visual field assessment of the far periphery (60-4) and/or central visual field (10-2) enables earlier detection of  glaucomatous optic neuropathy.

  • Glaucoma Biomarkers Rochester, MN

    Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments. Current trial-and error approaches to glaucoma management are inefficient and have not addressed this barrier as there are no predictive factors for drug response. Our long-term goal is to improve outcomes by identifying biomarkers and environmental factors that profile a patient at risk for glaucoma by age-of-onset, rate of disease progression, "poor response" to treatment, and large IOP fluctuation. Our purpose of this research project is to address this ...

  • Ocular Hypertension Treatment Study (OHTS) Scottsdale/Phoenix, AZ; Rochester, MN

    To determine whether medical reduction of intraocular pressure prevents or delays the onset of glaucomatous visual field loss and/or optic disc damage in ocular hypertensive participants judged to be at moderate risk for developing open-angle glaucoma. To produce natural history data to assist in identifying patients at most risk for developing open-angle glaucoma and those most likely to benefit from early medical treatment. To quantify risk factors for developing open-angle glaucoma among ocular hypertensive individuals.

  • A Study to Further Characterize the Complications in Glaucoma Patients Treated with Surgery Versus Medication Rochester, MN

    The purpose of this study is to further characterize the complications in glaucoma patients treated with surgery versus medication. The plan is to investigate visual outcomes of surgical and medical glaucoma interventions and interrogate potential risk factors associated with complications.

  • Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-angle Glaucoma or Ocular Hypertension Jacksonville, FL

    This study will evaluate the efficacy and safety of bimatoprost sustained-release (SR) in patients with open-angle glaucoma or ocular hypertension. The study includes a 12-month treatment period with an 8-month extended follow-up.

  • A Comparison of Two Ab Interno Procedures in the Treatment of Glaucoma in Patients Undergoing Cataract Extraction Jacksonville, FL

    The purpose of this study is to compare the safety and efficacy of goniotomy performed with a novel ophthalmic knife compared to trabecular bypass stent implantation in mild to moderate glaucoma subjects who are also undergoing cataract extraction with phacoemulsification (Phaco) and posterior chamber intraocular lens (PCIOL) implant.

  • Post Approval Study of the CyPass System in Patients with Primary Glaucoma Undergoing Cataract Surgery Jacksonville, FL

    The purpose of this study is to analyze the rate of clinically relevant
    complications associated with CyPass Micro-Stent (CyPass)
    as determined at 36 months in patients with primary glaucoma undergoing cataract surgery.

  • Risk of Ptosis following Glaucoma Tube Shunt Placement Rochester, MN

    The prupose of this study is to determine the incidence and amount of ptosis after tube shunt placement compared to other types of anterior segment surgery.

  • Diplopia and Quality of Life in Patients with Baerveldt 250 Compared to Ahmed FP7 Glaucoma Drainage Devices Rochester, MN

    The purpose of our prospective study is to compare the prevalence of diplopia following 250 Baerveldt and FP7 Ahmed, and to characterize the specific types, causes, and effect of diplopia in these two groups.

  • A Study to Evaluate the Effect of Latanoprostene Bunod Ophthalmic Solution 0.024% on Episcleral Venous Pressure and Outflow Facility in Participants With Ocular Hypertension Rochester, MN

    The primary purpose of this study is to determine the effect of latanoprostene bunod (LBN) ophthalmic solution 0.024% (a single dose and 7 days of once daily [QD] dosing) on 2 aspects of aqueous humor (AqH) dynamics (episcleral venous pressure [EVP] and outflow facility) in participants with ocular hypertension (OHT).

  • Outcome Measures for Clinical Trials in Pediatric Eye Care and Strabismus Rochester, MN

    This study is being done to:

    - Assess what children with different eye conditions experience in everyday life

    - Improve our understanding of the difficulties that children with eye problems experience

    - Improve reporting of how parents see their child’s eye condition affecting them

    - Assess what parents of children with different eye conditions experience in their own everyday life

    - Improve the way we assess the benefits of treatment


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