Risk Factors for Exfoliation Syndrome, Exfoliation Glaucoma and Primary Open Angle Glaucoma


About this study

We are doing this research study to find out the genetic and environmental factors that contribute to glaucoma (high pressure in the eye), which can cause vision loss and blindness if untreated. Exfoliation syndrome is a common condition that can lead to exfoliation glaucoma. The most common form of glaucoma is called primary open angle glaucoma. Identifying the factors that lead to exfoliation syndrome and glaucoma may help us to develop future tests and treatments for these conditions.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria: Cases

  • Exfoliation Syndrome
  • Exfoliation Glaucoma
  • Angle Closure Glaucoma
  • Primary Open Angle Glaucoma

Exclusion Criteria: Cases

  • None for exfoliation status but glaucoma not mentioned above will be scored as unknown
  • Individuals who have received chronic steroid therapy


Individuals will be scored as unaffected if the following criteria are met:

  • absence of exfoliation material either at clinical exam or in clinical records,
  • IOP without treatment less than 22 mmHg, and
  • No evidence of glaucomatous optic nerve disease (symmetric vertical cup to disc ratio of less than 0.6), and
  • age >60 as ES is strongly age-related.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Arthur Sit, M.D.

Open for enrollment

Contact information:

Elainey Wada

(507) 538-4122


More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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