Allergies

Displaying 13 studies

  • A Study of the Presence of Follicular T Cells in the Peripheral Blood of People with Nasal Allergies to Ragweed Rochester, MN; Scottsdale/Phoenix, AZ

    The purpose of this study is to measure the presence of follicular T cells in the peripheral blood of people who have a nasal allergy response to ragweed.

  • Allergy Skin Patch Testing to Increase Efficiency and Scale of the Practice Jacksonville, FL

    The purpose of this study is to assess human and AI performance in grading contact dermatitis reactions in healthy volunteers.

  • Study to Evaluate the Efficacy and Safety of MEDI9929 (AMG 157) in Adult Subjects With Inadequately Controlled, Severe Asthma Rochester, MN

    The primary objective of the study is to evaluate the effect of 3 dose levels of MEDI9929 (AMG 157) on asthma exacerbations in adult subjects with inadequately controlled, severe asthma.

  • Mayo Clinic Drug Allergy Repository Jacksonville, FL; Scottsdale/Phoenix, AZ; Scottsdale/Phoenix, AZ; Eau Claire, WI

    The purpose of this study is to build a Mayo Clinic registry of data and biobank from subjects with drug allergy. The data collected will include demographic, diagnostic, and health data on a large group of patients to discover novel drug allergy diagnostic methods.

  • Monitoring Adverse Gastrointestintal Events In Cow’s Milk Immunotherapy Using the Esophageal STRING Test (MAGIC-STRING) Scottsdale/Phoenix, AZ

    The primary objective of this study is to evaluate markers of eosinophilic inflammation in the esophagus longitudinally in subjects on milk oral immunotherapy (OIT) or placebo.

    This is a companion study to a parent clinical trial which is a phase 2, multicenter, randomized, double-blind, parallel group, 2 arm study in subjects aged 4 to 50 years inclusive who are allergic to milk. The parent study consists of a screening period, a 24-week treatment period, which includes 4 weeks of pre-treatment with dupilumab or placebo followed by 12 weeks of treatment with dupilumab or placebo in combination with a gradual up-dosing of milk protein ...

  • A Study to Create a Repository for Drug Allergy Patients Scottsdale/Phoenix, AZ; Jacksonville, FL; Rochester, MN

    This protocol outlines a prospective data collection effort from Allergy specialists at several academic and clinical institutions with the main goal of establishing and achieving a broad network and collection of allergy data consisting of clinical data and patient reported outcomes. 

  • A Study to Evaluate the Safety and Effectiveness of Dupilumab and Milk Oral Immunotherapy to Treat Patients with Cow's Milk Allergy Scottsdale/Phoenix, AZ

    The purpose of this study is to assess whether dupilumab as an adjunct to milk oral immunotherapy (OIT) compared to placebo improves desensitization and safety, defined as an increase in the proportion of subjects who pass a double-blind placebocontrolled food challenge (DBPCFC) to at least 2040 mg cumulative milk protein at week 18.

  • Study to Identify Allergen Epitopes in Individuals with Peanut Allergy Jacksonville, FL

    The purpose of this study is to use samples from multiple patients to validate and provide detailed mapping of food to identify allergen epitopes.  This will provide crucial data to the study of the molecular basis of food allergy.

  • Collection of Tissue and Blood in Patients with Allergic and Immunologic Disorders Scottsdale/Phoenix, AZ

    Allergic and immunologic disorders are very common but some are very poorly understood. Numerous studies of the epidemiology, characteristics, diagnosis and treatment of these disorders are urgently needed to identify and optimally treat affected patients. Though numerous challenges impact the progress of research in this area, specimens are needed to test new hypotheses and methodologies.  We aim to create a registry and biorepository of tissue and fluid specimens for future studies.

  • Factors Contributing to Underutilization of Epinephrine for Allergy Anaphylaxis Jacksonville, FL; Rochester, MN

    The purpose of this study is to evaluate the rate of compliance for having an emergency epinephrine autoinjector readily accessible in adults with allergies, and to determine factors that negatively influence adults with allergies for having an emergency epinephrine autoinjector readily accessible.

  • Fecal Microbiota and its Association with Food Allergies in Children Rochester, MN

    Our long term aim is identify unique microbiota associated with allergic disease, esp. food allergies and its association with allergic disease state (persistence of food allergies Vs. outgrowth of food allergies) which in turn will facilitate the use of probiotics to decrease the disease burden of allergic diseases.

  • Clinical Criteria for the Diagnosis of Anaphylaxis in Emergency Department Patients Rochester, MN

    The goal is to assess the criterion and predictive validity of the diagnostic criteria for anaphylaxis proposed by the 2nd Symposium on the Definition and Management of Anaphylaxis. Determination of the clinical utility of the diagnostic criteria is essential for the criteria to be widely adopted into clinical practice.  Prospectively, the NIAID/FAAN criteria continued to be highly sensitive (95%) but had lower specificity (71%) than on retrospective assessment. These criteria are likely to be useful for the diagnosis of anaphylaxis in the ED.

  • Excretion of Mast Cell Mediators in Children with Allergic Disorders Rochester, MN

    The aim of this study is to examine the role of mast cell mediators in children with allergic disorders in a two part study. Part 1 of the study will prospectively obtain the values of mast cell mediators, including 2,3 dinor 11β-PGF2α, n-MH, and LTE4 in the urine of a healthy pediatric reference population. Part 2 of the study will prospectively evaluate the urine concentrations of mast cell mediators in a cohort of pediatric allergic disorder patients including asthma, allergic rhinoconjunctivitis, eczema, urticaria, systemic anaphylaxis, and mast cell disorders, as well as POTS (postural orthostatic tachycardia syndrome). Comparisons of these ...

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