Collection of Tissue and Blood in Patients with Allergic and Immunologic Disorders

Overview

About this study

Allergic and immunologic disorders are very common but some are very poorly understood. Numerous studies of the epidemiology, characteristics, diagnosis and treatment of these disorders are urgently needed to identify and optimally treat affected patients. Though numerous challenges impact the progress of research in this area, specimens are needed to test new hypotheses and methodologies.  We aim to create a registry and biorepository of tissue and fluid specimens for future studies.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria: 

  • All patients with a suspected allergic or immunologic disorder undergoing endoscopy for symptoms of esophageal dysfunction between the ages of 0 to 80 will be eligible for participation in this study
  • All subjects with known eosinophilic esophagitis and off treatment between the ages of 0 to 80 will be eligible for participation in this study

Exclusion Criteria:

  • Previous therapy within 6 weeks with oral or swallowed steroids or strict dietary elimination of major allergens* (milk, egg, wheat, soy, peanut, tree nuts, seafood).
  • Previous esophageal congenital disorders such as tracheal esophageal fistula and esophageal atresia.
  • Known (prevalent) diagnosis an eosinophilic gastrointestinal disorder other than EoE.
  • Gastrointestinal bleeding or active anticoagulation.
  • Known esophageal cancer.
  • Prior esophageal surgery.
  • Known esophageal varices.
  • Medical instability or multiple comorbidities precluding enrollment in the clinical opinion of the endoscopist.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Benjamin Wright, M.D.

Open for enrollment

Contact information:

Benjamin Wright M.D.

(480)301-8000

Wright.Benjamin@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

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CLS-20338640

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