Cardiomyopathy and heart failure affect millions of Americans, resulting in billions of dollars for related health care annually. The mission of the Zebrafish Genetics Laboratory is to utilize zebrafish as an animal model to elucidate molecular mechanisms of human cardiomyopathy and to develop novel therapies. Toward this goal, the first several adult zebrafish models of human cardiomyopathies have been generated and a mutagenesis screen-based strategy established that enables systematic identification of genetic modifiers for cardiomyopathy. Novel therapeutic strategies are being derived from this screen, which will be tested in different types of cardiomyopathy. By integrating the efficient zebrafish model with in vitro cell culture systems and in vivo rodent models, individualized medicine for people with cardiomyopathy can be achieved.