Publications

  1. Ding Y, Dvornikov AV, Ma X, Zhang H, Wang Y, Lowerison M, Packard RR, Wang L, Chen J, Zhang Y, Hsiai T, Lin X, Xu X. Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish. Dis Model Mech. 2019 Oct 1; 12 (10) Epub 2019 Oct 01
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  2. Dvornikov AV, Wang M, Yang J, Zhu P, Le T, Lin X, Cao H, Xu X. Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy. J Mol Cell Cardiol. 2019 Aug; 133:199-208 Epub 2019 June 20
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  3. Chen J, Ding Y, Chen M, Gau J, Jen N, Nahal C, Tu S, Chen C, Zhou S, Chang CC, Lyu J, Xu X, Hsiai TK, Packard RRS. Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration. JCI Insight. 2019 Apr 18; 4 (8)
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  4. Dvornikov AV, de Tombe PP, Xu X. Phenotyping cardiomyopathy in adult zebrafish. Prog Biophys Mol Biol. 2018 Oct; 138:116-125 Epub 2018 May 30
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  5. Zhang H, Dvornikov AV, Huttner IG, Ma X, Santiago CF, Fatkin D, Xu X. A Langendorff-like system to quantify cardiac pump function in adult zebrafish. Dis Model Mech. 2018 Sep 10; 11 (9) Epub 2018 Sept 10
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  6. Ma X, Ding Y, Wang Y, Xu X. A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish. J Vis Exp. 2018 Jun 7; (136) Epub 2018 June 07
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  7. Lenning M, Fortunato J, Le T, Clark I, Sherpa A, Yi S, Hofsteen P, Thamilarasu G, Yang J, Xu X, Han HD, Hsiai TK, Cao H. Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection. Sensors (Basel). 2017 Dec 28; 18 (1)
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  8. Packard RRS, Baek KI, Beebe T, Jen N, Ding Y, Shi F, Fei P, Kang BJ, Chen PH, Gau J, Chen M, Tang JY, Shih YH, Ding Y, Li D, Xu X, Hsiai TK. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Sci Rep. 2017 Aug 17; 7 (1):8603
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  9. Long PA, Theis JL, Shih YH, Maleszewski JJ, Abell Aleff PC, Evans JM, Xu X, Olson TM. Recessive TAF1A mutations reveal ribosomopathy in siblings with end-stage pediatric dilated cardiomyopathy. Hum Mol Genet. 2017 Aug 1; 26 (15):2874-2881
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  10. Wang L, Ma X, Xu X, Zhang Y. Systematic identification and characterization of cardiac long intergenic noncoding RNAs in zebrafish. Sci Rep. 2017 Apr 28; 7 (1):1250
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  11. Fei YD, Li W, Hou JW, Guo K, Chen XM, Chen YH, Wang Q, Xu XL, Wang YP, Li YG. Oxidative Stress-Induced Afterdepolarizations and Protein Kinase C Signaling. Int J Mol Sci. 2017 Mar 30; 18 (4)
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  12. Zhu P, Sieben CJ, Xu X, Harris PC, Lin X. Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model. Hum Mol Genet. 2017 Jan 1; 26 (1):158-172
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  13. Shih YH, Dvornikov AV, Zhu P, Ma X, Kim M, Ding Y, Xu X. Exon- and contraction-dependent functions of titin in sarcomere assembly. Development. 2016 Dec 15; 143 (24):4713-4722 Epub 2016 Nov 11
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  14. Ding Y, Long PA, Bos JM, Shih YH, Ma X, Sundsbak RS, Chen J, Jiang Y, Zhao L, Hu X, Wang J, Shi Y, Ackerman MJ, Lin X, Ekker SC, Redfield MM, Olson TM, Xu X. A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene. JCI Insight. 2016 Sep 8; 1 (14)
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  15. Long PA, Zimmermann MT, Kim M, Evans JM, Xu X, Olson TM. De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy. Hum Genet. 2016 Aug; 135 (8):909-917 Epub 2016 May 27
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  16. Li X, Luo R, Fang W, Xu X, Niu G, Xu Y, Fu M, Hua W, Wu X. Effects of ventricular conduction block patterns on mortality in hospitalized patients with dilated cardiomyopathy: a single-center cohort study. BMC Cardiovasc Disord. 2016 Jun 13; 16:136 Epub 2016 June 13
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  17. Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK. Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Sci Rep. 2016 Mar 3; 6:22489 Epub 2016 Mar 03
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  18. Yang J, Shah S, Olson TM, Xu X. Modeling GATAD1-Associated Dilated Cardiomyopathy in Adult Zebrafish. J Cardiovasc Dev Dis. 2016 Mar; 3 (1) Epub 2016 Jan 26
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  19. Zhu P, Xu X, Lin X. Both ciliary and non-ciliary functions of Foxj1a confer Wnt/beta-catenin signaling in zebrafish left-right patterning. Biol Open. 2015 Oct 2; 4 (11):1376-86 Epub 2015 Oct 02
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  20. Shih YH, Zhang Y, Ding Y, Ross CA, Li H, Olson TM, Xu X. Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish. Circ Cardiovasc Genet. 2015 Apr; 8 (2):261-9 Epub 2015 Jan 11
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  21. Sun Y, Fang Y, Xu X, Lu G, Chen Z. Evidence of an association between age-related functional modifications and pathophysiological changes in Zebrafish heart. Gerontology. 2015; 61(5):435-47.
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  22. Yang J, Shih YH, Xu X. Understanding cardiac sarcomere assembly with zebrafish genetics. Anat Rec (Hoboken). 2014 Sep; 297 (9):1681-93
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  23. Yang J, Hartjes KA, Nelson TJ, Xu X. Cessation of contraction induces cardiomyocyte remodeling during zebrafish cardiogenesis. Am J Physiol Heart Circ Physiol. 2014 Feb; 306 (3):H382-95 Epub 2013 Dec 06
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  24. Li X, Luo R, Gu H, Deng Y, Xu X, Wu X, Hua W. Cardiac troponin T (TNNT2) mutations in chinese dilated cardiomyopathy patients. Biomed Res Int. 2014; 2014:907360 Epub 2014 July 07
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  25. Campbell JM, Hartjes KA, Nelson TJ, Xu X, Ekker SC. New and TALENted genome engineering toolbox. Circ Res. 2013 Aug 16; 113 (5):571-87
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  26. Ding Y, Liu W, Deng Y, Jomok B, Yang J, Huang W, Clark KJ, Zhong TP, Lin X, Ekker SC, Xu X. Trapping cardiac recessive mutants via expression-based insertional mutagenesis screening. Circ Res. 2013 Feb 15; 112 (4):606-17 Epub 2013 Jan 02
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  27. Bishu K, Ogut O, Kushwaha S, Mohammed SF, Ohtani T, Xu X, Brozovich FV, Redfield MM. Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade. PLoS One. 2013; 8 (12):e81325 Epub 2013 Dec 03
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  28. Yang J, Xu X. alpha-Actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis. FASEB J. 2012 Oct; 26 (10):4230-42 Epub 2012 July 05
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  29. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Banhegyi G, Bartholomew CR, Bassham DC, Bast RC Jr, Batoko H, Bay BH, Beau I, Bechet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronje MJ, Cuervo AM, Cullen JJ, Czaja MJ, Feng Y, Fisher PB, Garcia L, Ghosh P, Harris J, Huang J, Hurley JB, Jackson WT, Jiang H, Jimenez A, Johnson DE, Kumar R, Lee GM, Lee JH, Lee SH, Li F, Liu W, McLean PJ, Meyer TF, Moore MN, Prasad A, Reed JC, Ryan KM, Sanchez AM, Schwartz GK, Smith DR, Sood AK, Tang D, Taylor GA, Wang C, Wang F, Wang G, Wang J, Wang Z, Weiss WA, Xu X, Yu L, Zhang XD. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8 (4):445-544
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  30. Caron A, Xu X, Lin X. Wnt/beta-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development. 2012 Feb; 139 (3):514-24 Epub 2011 Dec 21
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  31. Kushwaha S, Xu X. Target of rapamycin (TOR)-based therapy for cardiomyopathy: evidence from zebrafish and human studies. Trends Cardiovasc Med. 2012 Feb; 22 (2):39-43 Epub 2012 July 28
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  32. Yang J, Xu X. Immunostaining of dissected zebrafish embryonic heart. J Vis Exp. 2012 Jan 10; (59):e3510
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  33. Ding Y, Sun X, Xu X. TOR-autophagy signaling in adult zebrafish models of cardiomyopathy. Autophagy. 2012 Jan; 8 (1):142-3 Epub 2012 Jan 01
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  34. Hoage T, Ding Y, Xu X. Quantifying cardiac functions in embryonic and adult zebrafish. Methods Mol Biol. 2012; 843:11-20
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  35. Sun X, Xu X. Anemic zebrafish models of cardiomyopathy. Methods in Pharmacology and Toxicology. 2012; 41-54.
  36. Hoage T, Sun X, Xu X. Functions of the Wnt/beta-catenin pathway in an anemia-induced zebrafish model of cardiomyopathy are location dependent. Biochem Biophys Res Commun. 2011 Nov 25; 415 (3):490-6 Epub 2011 Oct 28
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  37. Ding Y, Sun X, Huang W, Hoage T, Redfield M, Kushwaha S, Sivasubbu S, Lin X, Ekker S, Xu X. Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish. Circ Res. 2011 Sep 2; 109 (6):658-69 Epub 2011 July 14
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  38. Clark KJ, Balciunas D, Pogoda HM, Ding Y, Westcot SE, Bedell VM, Greenwood TM, Urban MD, Skuster KJ, Petzold AM, Ni J, Nielsen AL, Patowary A, Scaria V, Sivasubbu S, Xu X, Hammerschmidt M, Ekker SC. In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Nat Methods. 2011 Jun; 8 (6):506-15 Epub 2011 May 08
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  39. Zhang R, Yang J, Zhu J, Xu X. Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly. Hum Mol Genet. 2009 Nov 1; 18 (21):4130-40 Epub 2009 Aug 12
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  40. Sun X, Hoage T, Bai P, Ding Y, Chen Z, Zhang R, Huang W, Jahangir A, Paw B, Li YG, Xu X. Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PLoS One. 2009 Aug 12; 4 (8):e6596
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  41. Huang W, Zhang R, Xu X. Myofibrillogenesis in the developing zebrafish heart: A functional study of tnnt2. Dev Biol. 2009 Jul 15; 331 (2):237-49 Epub 2009 May 07
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  42. Zhang R, Xu X. Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: an inhibitory mechanism of ventricle-specific gene expression. Dev Dyn. 2009 Jun; 238 (6):1564-73
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  43. Lin X, Xu X. Distinct functions of Wnt/beta-catenin signaling in KV development and cardiac asymmetry. Development. 2009 Jan; 136 (2):207-17
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  44. Chen Z, Huang W, Dahme T, Rottbauer W, Ackerman MJ, Xu X. Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms. Cardiovasc Res. 2008 Jul 1; 79(1):97-108. Epub 2008 Mar 14.
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  45. Sun X, Zhang R, Lin X, Xu X. Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6. Circ Res. 2008 Apr 11; 102(7):831-9. Epub 2008 Feb 21.
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  46. Wang L, Dutta SK, Kojima T, Xu X, Khosravi-Far R, Ekker SC, Mukhopadhyay D. Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival. PLoS One. 2007 Nov 14; 2 (11):e1161
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  47. Lin X, Rinaldo L, Fazly AF, Xu XL. Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis. Dev Biol. 2007 Mar 15; 303(2):536-48.
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  48. Rich A, Leddon SA, Hess SL, Gibbons SJ, Miller S, Xu X, Farrugai G. Kit-like immunoreactivity in the zebrafish gastrointestinal tract reveals putative ICC. Dev Dyn. 2007 Mar; 236(3):903-11.
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  49. Seeley M, Huang W, Chen Z, Wolff WO, Lin X, Xu X. Depletion of zebrafish titin reduces cardiac contractility by disrupting the assembly of Z-discs and A-bands. Circ Res. 2007 Feb 2; 100 (2):238-45 Epub 2006 Dec 14
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  50. Wang L, Mukhopadhyay D, Xu X. C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis. FASEB J. 2006 Jul; 20(9):1513-5. Epub 2006 Jun 05.
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  51. Bos JM, Poley RN, Ny M, Tester DJ, Xu X, Vatta M, Towbin JA, Gersh BJ, Ommen SR, Ackerman MJ. Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin. Mol Genet Metab. 2006 May; 88 (1):78-85 Epub 2005 Dec 13
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  52. Xu X, Meiler SE, Zhong TP, Mohideen M, Crossley DA, Burggren WW, Fishman MC. Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nat Genet. 2002 Feb; 30(2):205-9.
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  53. Zaffran S, Xu X, Lo PC, Lee HH, Frasch M. Cardiogenesis in the Drosophila model: control mechanisms during early induction and diversification of cardiac progenitors. Cold Spring Harb Symp Quant Biol. 2002; 67:1-12.
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  54. Nguyen HT, Xu X. Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules. Dev Biol. 1998 Dec 15; 204(2):550-66.
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  55. Xu X, Yin Z, Hudson JB, Ferguson EL, Frasch M. Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 1998 Aug 1; 12(15):2354-70.
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  56. Yin Z, Xu X, Frasch M. Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development. 1997 Dec; 124(24):4971-82.
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  57. Zhou Y, Xu X, Liu Z, Zhao S. Analysis of the transcriptional regulation by the 5'-upstream sequences of Tumor Necrosis Factor. Chinese Science Bulletin. 1992; 37(1):74-7.