This image shows the delicate alveolar architecture of the lung, as seen by immunofluorescence imaging of laminin

The Tissue Repair and Mechanobiology laboratory of Daniel J. Tschumperlin, Ph.D., at Mayo Clinic in Rochester, Minn., investigates diseases of the respiratory system, with a focus on the cellular and molecular mechanisms of lung repair, remodeling and fibrosis. These processes are central to a variety of lung disorders, including pulmonary fibrosis, chronic obstructive pulmonary disease and asthma.

The lung is exquisitely designed to support life through its immense yet exceedingly thin gas exchange surface. Lung function depends on the interactions of numerous cell types within a delicate architectural framework. The lab investigates how injury and remodeling disturb the matrix architecture and mechanical forces present in the normal lung, as well as how the interplay among the mechanical environment, cellular signaling and tissue remodeling result in organ dysfunction.

By understanding how cells of the lung sense, respond to and shape the mechanical environment of the lung in health and disease, the lab is working toward developing new approaches to prevent or reverse aberrant remodeling and lung dysfunction.