The Tissue Repair and Mechanobiology Laboratory of Daniel J. Tschumperlin, Ph.D., at Mayo Clinic in Rochester, Minnesota, investigates diseases of the respiratory system with a focus on the cellular and molecular mechanisms of lung repair, remodeling and fibrosis. These processes are central to a variety of lung disorders, including pulmonary fibrosis, chronic obstructive pulmonary disease and asthma.

The lung is exquisitely designed to support life through its immense yet exceedingly thin gas exchange surface. Lung function depends on the interactions of numerous cell types within a delicate architectural framework. The Tissue Repair and Mechanobiology Laboratory investigates how injury and remodeling disturb the matrix architecture and mechanical forces present in the healthy lung, and how the interplay among the mechanical environment, cellular signaling and tissue remodeling result in organ dysfunction.

By understanding how cells of the lung sense, respond to and shape the mechanical environment of the lung in health and disease, Dr. Tschumperlin's research team is working toward developing new approaches to prevent or reverse aberrant remodeling and lung dysfunction.

Focus areas include:

  • Mechanobiology of pulmonary fibrosis. Dr. Tschumperlin's research team is defining the changes in tissue stiffness that accompany pulmonary fibrosis and studying the signaling mechanisms that regulate it.
  • Discovering novel regulators of myofibroblast biology. The lab's research is aimed at discovering new regulatory pathways that control the activation of myofibroblasts — the cells that cause fibrosis.
  • Cell-cell communication and lung repair. The lab is investigating how optimal lung structure and function are maintained and restored after injury through coordinated interactions of multiple cell types, including epithelial, endothelial and fibroblast.


Dr. Tschuperlin's lab is affiliated with these Mayo Clinic research areas:

About Dr. Tschumperlin

Daniel J. Tschumperlin, Ph.D., is vice chair of Mayo Clinic's Department of Physiology and Biomedical Engineering. He also holds a joint appointment in the Division of Pulmonary and Critical Care Medicine.