Schematic representation of neuromuscular transmission

Neuromuscular transmission effectively transduces electrical signals in neurons into electrical and mechanical activity in muscles. Understanding the regulation of this important chemical step across diseases conditions and regeneration is a focus of Dr. Mantilla's laboratory.

Representative diaphragm neuromuscular junctions and evidence of synaptic vesicle release identified by reduced FM4-64 fluorescence.

Live imaging allows understanding molecular and cellular mechanisms of disease and regeneration.

3-D reconstruction of labeled phrenic motor neuron

Structure-function relationships are important to understand neuroplasticity and regeneration and actively explored in Dr. Mantilla's laboratory.