Schematic representation of neuromuscular transmission

Neuromuscular transmission effectively transduces electrical signals in neurons into electrical and mechanical activity in muscles. Dr. Mantilla is studying the regulation of this important chemical step across diseases, conditions and regeneration.

Representative diaphragm neuromuscular junctions and evidence of synaptic vesicle release identified by reduced FM4-64 fluorescence

Live imaging enables a better understanding of the molecular and cellular mechanisms of disease and regeneration.

3D reconstruction of labeled phrenic motor neuron

Dr. Mantilla is studying structure-function relationships to gain a better understanding of neuroplasticity and regeneration.