Overview

The Regenerative Neurobiology Laboratory led by Anthony J. Windebank, M.D., seeks to understand the cellular mechanisms underlying injury and repair in the nervous system. There are four major disease areas:

• Spinal cord injury.
• Peripheral nerve injury.
• Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
• Chemotherapy-induced peripheral neuropathy.

The lab studies these conditions using state-of-the-art technology that includes genetic epidemiology, model systems, cell and molecular biology, and multiple forms of imaging.

The lab also develops and leads clinical trials using cell-based therapy and tissue engineering approaches to treating neurological disease. Extensive collaborations with the Center for Clinical and Translational Science (CCaTS) and the Center for Regenerative Biotherapeutics facilitate this work.

Dr. Windebank's lab research includes repair and regeneration after peripheral nerve or spinal cord injury, treatment of ALS, and the mechanism of neuronal cell death caused by chemotherapeutic agents. His lab coordinates the research activities of a multidisciplinary team, with specialists from neuroscience, biochemistry and molecular biology, physiology and biomedical engineering, neurology, neurosurgery, physical medicine and rehabilitation, orthopedics, and Mayo Clinic Comprehensive Cancer Center — Research.

Affiliations

Mayo Clinic research groups and programs affiliated with the Regenerative Neurobiology Lab include:

• Advanced Clinical Trials and Translational Sciences Research Program
• Center for Clinical and Translational Science (CCaTS)
• Center for Regenerative Biotherapeutics
• Mayo Clinic Comprehensive Cancer Center — Research
• Neurology — Research
• Novel Therapeutics and Therapeutic Modalities Research Program
• Ph.D. Program:
  • Clinical and Translational Science Track
  • Neuroscience Track