Clinical Trials

The Precision Medicine for Obesity Lab at Mayo Clinic has ongoing clinical trials that are actively recruiting patient volunteers. These trials support our research goals that aim to make cutting-edge discoveries about human obesity.

Learn more about our clinical trials below, and contact us at for more information.

A study to evaluate individualized lifestyle intervention for obesity management based on obesity phenotypes

Participants will take part in the Healthy Living Program's 2-day Mayo Clinic Diet experience, during which they will complete a full metabolic analysis and work with our team of registered dietitians, exercise specialists, physical therapists, resiliency specialists, wellness coaches, and wellness chef. Participants will have weekly meetings with their wellness coach (for 12 weeks). The study includes 7 total visits, including a day of phenotyping tests before the 2-day Mayo Clinic Diet experience and another day of phenotyping at 12 weeks.

Anti-obesity phentermine-topiramate extended release pharmacotherapy vs placebo among patients using a wearable activity tracker

For this study, patients are randomized to either a placebo or phentermine-topiramate for 13 months. Patients also use activity trackers that are paired to an application on their iPhone for the duration of the study. After completing testing and being randomized to the medication, patients complete virtual visits or in-person visits monthly.

Setmelanotide phase 2 treatment trial in patients with rare genetic disorders of obesity

The purpose of this research is to find out if an investigational medication called setmelanotide is safe and can help control body weight and hunger in people with specific genetic disorders of obesity.

Bariatric surgery versus diet alone in the bile acid pathway and weight loss

This study will evaluate the effect of weight loss with bariatric Surgery vs. Diet Alone in bile acid pathway. Participants will be in this study for up to 12 weeks and meals will be provided.

Characterization of bile acid pathway in obesity

This study will evaluate the role of bile acids in food intake and body weight regulation in participants with obesity compared to normal weight individuals. The study consists of eight visits to Mayo Clinic and includes 4 weeks of diet monitoring, 2 of which include the investigational diet.

A study of individualized obesity pharmacotherapy based on obesity phenotypes

This study is to identify the specific characteristics (phenotypes) that may be useful to help select the right weight loss medication for the right patient. This study includes a total of 9 visits. Participants will complete a full metabolic analysis and eligible participants will receive medications for weight loss for 12 weeks.

A study to establish an obesity-related phenotype registry

The purpose of this study is to create a registry of obese patients who have been phenotyped to understand the heterogeneity of obesity.