Overview

The Musculoskeletal Biology and Immunology Laboratory of Anne Gingery, Ph.D., takes an integrated systems-level approach to studying musculoskeletal pathologies. Our aims are to uncover underlying mechanisms of disease and develop prevention strategies and therapeutics to promote musculoskeletal health and the healthspan.

Our lab investigates the local and systemic effects of aging, cellular senescence, immune dysregulation and metabolic dysfunction across a broad spectrum of musculoskeletal conditions. Using a variety of approaches, we identify evidence-based mechanisms that drive disease and tissue repair.

Focus areas

• Investigating the mechanisms of connective tissue fibrosis in musculoskeletal disorders, including carpal tunnel syndrome, Dupuytren contracture, wound healing, tendinopathies, tendon repair and injury.
• Studying the role of the immune system in driving musculoskeletal conditions.
• Exploring the role of aging and cellular senescence in musculoskeletal pathology.
• Developing evidence-based therapeutic targets for translation into clinical care.

Our research spans the full translational spectrum, from fundamental mechanistic discovery to clinical trials. We're committed to converting these insights into actionable strategies, including targeted therapeutics and approaches that promote systemic health across the lifespan. In the clinic, our lab and collaborators are conducting trials to remove disease-driving senescent cells and promote tissue regeneration in connective tissue pathologies.

Our ultimate goal is to develop evidence-based methods to prevent and treat musculoskeletal conditions so that people can stay healthy and active longer.

Career and training opportunities

Dr. Gingery's lab offers excellent opportunities for careers and education and training.

If you're interested in career opportunities in the Musculoskeletal Biology and Immunology Laboratory, email Dr. Gingery your curriculum vitae and a brief statement of your research interests.

Students, postdoctoral fellows, clinical fellows and residents interested in basic research or clinical and translational research in the field of musculoskeletal biology should contact Dr. Gingery for information about training and learning opportunities.