SUMMARY
Anne Gingery, Ph.D., uses an integrated systems approach to study pathologies found in the musculoskeletal system. Dr. Gingery seeks to drive mechanistic understanding and develop preventives and therapeutics to improve health span.
Dr. Gingery focuses on investigating the local and systemic impacts of aging, cellular senescence, immune dysregulation, and metabolic dysfunction in musculoskeletal diseases and conditions. These include carpal tunnel syndrome, Dupuytren contracture, rheumatoid arthritis, connective tissue fibrosis, tendinopathy, rotator cuff tears, tendon injury and repair, skeletal biology, and wound healing. The goal is to develop evidence-based preventives and therapeutics.
To discover evidence-based mechanisms that drive disease and healing, Dr. Gingery uses multidisciplinary, state-of-the-art approaches, including bioinformatics and spatial, single-cell, and metabolomic multi-omics. She and her collaborators conduct trials to remove senescent cells and promote tissue regeneration in connective tissue pathologies.
Focus areas
- Mechanisms of age-related musculoskeletal pathology.
- Cellular senescence in wound healing, regeneration and pathology.
- Immune system dysregulation in musculoskeletal pathology and healing.
- Early identification of immune changes in rheumatoid arthritis patients.
- Role of inflammatory conditions in skeletal pathology.
- Role of stem cell exhaustion in musculoskeletal tissue regeneration and pathology.
Significance to patient care
Dr. Gingery and her colleagues aim to provide evidenced-based preventives and therapeutics to delay or prevent chronic conditions. A healthy musculoskeletal system can improve the health span, allowing people to live more years that are healthy, active, productive and relatively disease free.
Professional highlights
- Research chair, Tendon Section, Orthopaedic Research Society, 2023-present.
- Challenge Award on Musculoskeletal Aging: Beyond Senescence, Robert and Arlene Kogod Center on Aging, Mayo Clinic, 2024.
- American Society for Bone and Mineral Research:
- Chair, Membership Education Committee, 2019-2023.
- Chair, Early Stage Investigator Committee, 2014-2019.
- Career Development Award in Orthopedics Research, Mayo Clinic, 2018-2020.