Clinicopathological Studies
Dr. Graff-Radford established the Mayo Clinic Brain Bank in 1991 on Mayo Clinic's Florida campus after more than 500 cases and controls to autopsy. The Mayo Clinic Brain Bank has continued to grow to more than 12,000 specimens. It is currently led by Dennis W. Dickson, M.D.
Drs. Graff-Radford and Dickson have co-authored more than 200 scientific publications, including studies showing that:
- Posterior cortical atrophy is most often due to Alzheimer's disease.
- Hippocampal sclerosis can be mistaken for Alzheimer's disease clinically.
- Alzheimer's disease pathology can be grouped into typical, limbic and hippocampal sparing, and the clinical picture and progression differs between these groups.
Related publications
- McCarty A, Jones D, Dickson D, Graff-Radford N. Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) in normal pressure hydrocephalus misinterpreted as atrophy: Autopsy and radiological evidence. Neurocase. 2019; doi:10.1080/13554794.2019.1617319.
- Graff-Radford N, Besser L, Crook J, Kukull W, Dickson D. Neuropathologic differences by race from the National Alzheimer's Coordinating Center. Alzheimer's & Dementia. 2016; doi:10.1016/j.jalz.2016.03.004.
- Murray M, Graff-Radford N, Ross O, Petersen, R, Duara R, Dickson D. Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: A retrospective study. The Lancet Neurology. 2011; doi:10.1016/S1474-4422(11)70156-9.
- Pao W, Dickson D, Crook J, Finch N, Rademakers, R, Graff-Radford N. Hippocampal sclerosis in the elderly: Genetic and pathologic findings, some mimicking Alzheimer disease clinically. Alzheimer Disease & Associated Disorders. 2011; doi:10.1097/WAD.0b013e31820f8f50.
- Tang-Wai D, Graff-Radford N, Boeve B, Dickson J, Parisi J, Crook R, Caselli R, Knopman D, Petersen R. Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy. Neurology. 2004; doi:10.1212/01.WNL.0000140289.18472.15.