Clinicopathological Studies

Dr. Graff-Radford established the brain bank in 1991 at Mayo Clinic's campus in Florida after more than 500 cases and controls to autopsy. The brain bank has continued to grow to more than 5,000 specimens and is currently led by Dennis W. Dickson, M.D.

Dr. Graff-Radford and Dr. Dickson have co-authored more than 200 scientific publications, including studies that show the following:

  • Posterior cortical atrophy is most often due to Alzheimer's disease.
  • Hippocampal sclerosis can be mistaken for Alzheimer's disease clinically.
  • Alzheimer's disease pathology can be grouped into typical, limbic and hippocampal sparing and the clinical picture and progression differs between these groups.

More recently, Dr. Graff-Radford and his colleagues have published a paper on the autopsy of African Americans with dementia and the pathological findings in a case of normal pressure hydrocephalus (NPH) that had the radiological finding of disproportionate enlargement of subarachnoid-space hydrocephalus (DESH), a feature of NPH.

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