Molecular Epidemiology Resource
Dr. Cerhan's Lymphoma Epidemiology Lab created and maintains the Molecular Epidemiology Resource, a database that houses all data for Dr. Cerhan's clinical projects, such as the Mayo Clinic Case-Control Study of Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia.
Data are also used by researchers throughout Mayo Clinic and around the world to identify clinical, epidemiologic, host genetic, biologic, tumor and treatment factors that impact lymphoma outcomes and survivorship.
As of 2017, participants include nearly 7,000 patients with lymphoma, age 18 years and older, enrolled within nine months of diagnosis at Mayo Clinic's campus in Rochester, Minnesota, or at the University of Iowa in Iowa City, Iowa, from Sept. 1, 2002, to June 30, 2015.
In 2015, Dr. Cerhan and his research collaborators expanded the Molecular Epidemiology Resource protocol to six more sites, creating the Lymphoma Epidemiology of Outcomes Study. The Molecular Epidemiology Resource continues to recruit participants as a Midwestern branch of the LEO cohort.
Mayo Clinic and external investigators may request data from either the Molecular Epidemiology Resource data collection or from the expanded LEO lymphoma study.
Data collection protocol
All participants are contacted every six months for the first three years after diagnosis and then annually after that to ascertain outcomes. Disease progression or relapse, re-treatment, transformation and new cancers are validated against medical records.
At enrollment, participants complete a medical history questionnaire, provide a blood specimen for DNA, plasma and serum, and give consent for researchers to access their medical records.
The Lymphoma Epidemiology Lab collects patient-reported outcomes and survivorship data through follow-ups at three, six and nine years.
Related study files
Researchers can learn more about the study by reviewing PDF files for study news, questionnaires and surveys: