Mayo Clinic Case-Control Study of Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

The Lymphoma Epidemiology Lab's case-control study tests hypotheses about the etiology of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.

Led by Dr. Cerhan, this study analyzes study participant data for:

  • Medical history
  • Pesticide exposure
  • Farming exposure
  • Diet
  • Early-life factors
  • Genetic susceptibility
  • Gene-by-environment interactions

Study protocol

Participants enrolled in the study were newly diagnosed patients with Hodgkin's lymphoma or non-Hodgkin's lymphoma, including chronic lymphocytic leukemia, from Minnesota, Iowa and Wisconsin seen at Mayo Clinic's campus in Rochester, Minnesota, from Sept. 1, 2002, to Dec. 31, 2013. Controls were patients from the same region without a history of lymphoma or leukemia who had a prescheduled general medical examination and were frequency matched on age, sex and residence.

Each participant donated a blood sample, and the lab banked serum, plasma and DNA. Participants also completed the Main Questionnaire, Farming and Pesticide Exposure Survey, Female History (for women), and Food Frequency Questionnaire.

Study outcomes

Although the study is no longer recruiting participants, data analysis is ongoing.

The study has been a major contributor to the International Lymphoma Epidemiology (InterLymph) Consortium, an open scientific forum for epidemiologic research in non-Hodgkin's lymphoma formed by the National Cancer Institute in 2001.

Grant funding allowed creation of the InterLymph Data Coordinating Center at Mayo Clinic. The Data Coordinating Center provides the InterLymph Consortium with the necessary infrastructure to expedite pooling of high-priority projects, including integrating and harmonizing data from InterLymph studies, facilitating data sharing and assisting in data analysis.

Related study files

Researchers can learn more about the study by reviewing PDF files for study news, questionnaires and surveys: