Lymphoma Epidemiology of Outcomes Study

The Lymphoma Epidemiology of Outcomes (LEO) cohort study is a multicenter study to better understand current and long-term unmet health needs of people diagnosed with non-Hodgkin's lymphoma. Dr. Cerhan's Lymphoma Epidemiology Lab at Mayo Clinic is coordinating the study.

Study goals

The aims of the LEO lymphoma study are to:

  • Expand recruitment to six new centers, with a goal of recruiting 8,700 patients newly diagnosed with non-Hodgkin's lymphoma, including 1,000 African-American participants and 1,400 Hispanic participants. This would bring the total cohort to 12,900 patients, including 3,700 patients with diffuse large B-cell lymphoma and 3,300 patients with follicular lymphomas.
  • Review all pathology diagnoses and build a non-Hodgkin's lymphoma tumor bank that includes hematoxylin and eosin slides, formalin-fixed, paraffin-embedded tissue samples, and extracted tumor DNA and RNA.
  • Collect a peripheral blood sample and bank DNA, serum, plasma and buffy coat in a central biorepository.
  • Annotate and harmonize all cases with clinical, epidemiologic, pathology and treatment data.
  • Prospectively follow patients in the cohort to ascertain disease progression or relapse, re-treatment, transformation, second cancers, survival (including cause of death), updated exposures, patient-reported outcomes, and other long-term health outcomes.
  • Facilitate research projects that use the LEO infrastructure and promote interactions with lymphoma clinical trial networks.

Dr. Cerhan's Lymphoma Epidemiology Lab is coordinating the LEO lymphoma study with these seven other study sites:

  • The University of Iowa
  • Emory University
  • Cornell University
  • MD Anderson Cancer Center
  • University of Miami
  • University of Rochester Medical Center
  • Washington University

The LEO study expands on the data collection protocol used to create and maintain the lab's Molecular Epidemiology Resource. Compared with the Molecular Epidemiology Resource, LEO data represents a geographically and demographically broader range of participants, and data collection incorporates a more expansive set of questions.

Learn about enrolling in the LEO study.

Related study files

Researchers can learn more about the study by reviewing PDF files for study news, questionnaires and surveys: