Publication Highlights

Research highlights from Dr. Brownfield's Lung Development and Regeneration Lab are featured in these selected publications.

Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity. Science Advances. 2021; doi:10.1126/sciadv.abf8609.

Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M; Tabula Muris Consortium, Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020; doi:10.1038/s41586-020-2499-y.

Tabula Muris Consortium. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature. 2020; doi:10.1038/s41586-020-2496-1.

Tabula Muris Consortium. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018; doi:10.1038/s41586-018-0590-4.

Ricca BL, Venugopalan G, Furuta S, Tanner K, Orellana WA, Reber CD, Brownfield DG, Bissell MJ, Fletcher DA. Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling. eLife. 2018; doi:10.7554/eLife.26161.

Nabhan A, Brownfield DG, Harbury PB, Krasnow MA, Desai TJ. Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells. Science. 2018; doi:10.1126/science.aam6603.

Nam S, Lee J, Brownfield DG, Chaudhuri O. Viscoplasticity enables mechanical remodeling of matrix by cells. Biophysical Journal. 2016; doi:10.1016/j.bpj.2016.10.002.

Vaughan A, Brumwell A, Gotts J, Xi Y, Brownfield DG, Tan K, Tan V, Liu F, Looney M, Matthay M, Rock J, Chapman HA. Lineage-negative progenitor cells mobilize to regenerate lung epithelium after major injury. Nature. 2015; doi:10.1038/nature14112.

Treutlein B, Brownfield DG, Wu A, Neff N, Mantalas G, Espinoza FH, Desai TJ, Krasnow MA & Quake S. Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq. Nature. 2014; doi:10.1038/nature13173.

Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014; doi:10.1038/nature12930.

Brownfield DG, Venugopalan G, Lo A, Mori H, Tanner K, Fletcher DA, Bissell MJ. Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules. Current Biology. 2013; doi10.1016/j.cub.2013.03.032.

Alcaraz J, Mori H, Ghajar CM, Brownfield D, Galgoczy R, Bissell MJ. Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening. Integrative Biology. 2011; doi:10.1039/c1ib00073j.

Chanson L, Brownfield D, Garbe JC, Kuhn I, Stampfer MR, Bissell MJ, LaBarge MA. Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cell. Proceedings of the National Academy of Sciences. 2011; doi:10.1073/pnas.1019556108.

Alcaraz J, Xu R, Mori H, Nelson CM Mroue R, Spencer VA, Brownfield D, Radisky DC, Bustamante C, Bissell MJ. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia.The EMBO Journal. 2008; doi:10.1038/emboj.2008.206.