Publication highlights
Review research highlights from Dr. Brownfield's Lung Development and Regeneration Lab:
Ribeiro RVP, Altarabsheh SE, Segamanasinghe DL, Lopez-Muralles IW, Garcia Moreno AS, Knop G, Al-Azzam F, Mallea J, Brownfield DG, Olson AC, Gibbard DF, Jing Y, Cheng K, Saddoughi SA. Preconditioning donor lungs with lung-derived exosomes mitigates ischemia-reperfusion injury in a warm ischemia porcine DCD model. Journal of Heart and Lung Transplantation. 2025.
Sawhney AS, Deskin BJ, Cai J, Gibbard D, Ali G, Utoft A, Qi X, Olson A, Hausman H, Sabol L, Holmberg S, Shah R, Warren R, De Langhe S, Inde Z, Sarosiek KA, Lemire E, Haber A, Wang L, Wei Z, Benedito R, Brownfield DG. A molecular circuit regulates fate plasticity in emerging and adult AT2 cells. Nature Communications. 2025.
Sawhney AS, Deskin BJ, Cai J, Gibbard D, Ali G, Utoft A, Qi X, Olson A, Hausman H, Sabol L, Holmberg S, Shah R, Warren R, De Langhe S, Benedito R, Inde Z, Sarosiek KA, Lemire E, Haber AL, Wang L, Wei Z, Brownfield DG. A molecular circuit regulates fate plasticity in emerging and adult AT2 cells. bioRxiv [Preprint]. 2025.
Brownfield DG, de Arce AD, Ghelfi E, Gillich A, Desai TJ, Krasnow MA. Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling. Nature Communications. 2022.
Lyu H, Warren R, Gao S, Klinkhammer K, Yuan T, Zhang JS, Brownfield D, Li X, De Langhe SP. Niche-mediated repair of airways is directed in an occupant-dependent manner. Cell Reports. 2022.
Pálovics R., Keller A., Schaum N, Tan W, Fehlmann T, Borja M, Kern F, Bonanno L, Calcuttawala K, Webber J, McGeever A, The Tabula Muris Consortium, Luo J, Oliveira Pisco A, Karkanias J, Neff NF, Darmanis S, Quake SR, Wyss-Coray T. Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature. 2022.
Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity. Science Advances. 2021.
Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M; Tabula Muris Consortium, Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020.
Tabula Muris Consortium. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature. 2020.
Nabhan A, Brownfield DG, Harbury PB, Krasnow MA, Desai TJ. Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells. Science. 2018.
Ricca BL, Venugopalan G, Furuta S, Tanner K, Orellana WA, Reber CD, Brownfield DG, Bissell MJ, Fletcher DA. Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling. eLife. 2018.
Tabula Muris Consortium. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018.
Nam S, Lee J, Brownfield DG, Chaudhuri O. Viscoplasticity enables mechanical remodeling of matrix by cells. Biophysical Journal. 2016.
Vaughan A, Brumwell A, Gotts J, Xi Y, Brownfield DG, Tan K, Tan V, Liu F, Looney M, Matthay M, Rock J, Chapman HA. Lineage-negative progenitor cells mobilize to regenerate lung epithelium after major injury. Nature. 2015.
Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014.
Treutlein B, Brownfield DG, Wu A, Neff N, Mantalas G, Espinoza FH, Desai TJ, Krasnow MA, Quake S. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature. 2014.
Brownfield DG, Venugopalan G, Lo A, Mori H, Tanner K, Fletcher DA, Bissell MJ. Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules. Current Biology. 2013.
Alcaraz J, Mori H, Ghajar CM, Brownfield D, Galgoczy R, Bissell MJ. Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening. Integrative Biology. 2011.
Chanson L, Brownfield D, Garbe JC, Kuhn I, Stampfer MR, Bissell MJ, LaBarge MA. Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cell. Proceedings of the National Academy of Sciences. 2011.
Alcaraz J, Xu R, Mori H, Nelson CM Mroue R, Spencer VA, Brownfield D, Radisky DC, Bustamante C, Bissell MJ. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. The EMBO Journal. 2008.