Selected Publications

Recent publications from the laboratory:

  • Ibrahim SH, Gores GJ, Hirsova P, Kirby M, Miles L, Jaeschke A, Kohli R. Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver International. 2014; doi:10.1111/liv.12353.
  • Ibrahim SH, Hirsova P, Tomita K, Bronk SF, Werneburg NW, Harrison SA, Goodfellow VS, Malhi H, Gores GJ. Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes. Hepatology. 2016; doi:10.1002/hep.28252.
  • Ibrahim SH, Hirsova P, Malhi H, Gores GJ. Animal models of nonalcoholic steatohepatitis: Eat, delete, and inflame. Digestive Diseases and Sciences. 2016; doi:10.1007/s10620-015-3977-1.
  • Tomita K, Freeman BL, Bronk SF, LeBrasseur NK, White TA, Hirsova P, Ibrahim SH. CXCL10-mediates macrophage, but not other innate immune cells-associated inflammation in murine nonalcoholic steatohepatitis. Scientific Reports. 2016; doi:10.1038/srep28786.
  • Hirsova P, Ibrahim SH, Gores GJ, Malhi H. Lipotoxic lethal and sublethal stress signaling in hepatocytes: Relevance to NASH pathogenesis. Journal of Lipid Research. 2016; doi:10.1194/jlr.R066357.
  • Hirsova P, Ibrahim SH, Verma VK, Morton LA, Shah VH, LaRusso NF, Gores GJ, Malhi H. Extracellular vesicles in liver pathobiology: Small particles with big impact. Hepatology. 2016; doi:10.1002/hep.28814.
  • Tomita K, Kohli R, MacLaurin BL, Hirsova P, Guo Q, Sanchez LHG, Gelbard HA, Blaxall BC, Ibrahim SH. Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis. JCI Insight. 2017; doi:10.1172/jci.insight.94488.
  • Tomita K, Niibe A, Kabashima A, Freeman BL, Bronk SF, Hirsova P, Ibrahim SH. Mixed lineage kinase 3 mediates the induction of cxcl10 by a stat1-dependent mechanism during hepatocyte lipotoxicity. Journal of Cellular Biochemistry. 2017; doi:10.1002/jcb.2597.
  • Ibrahim SH, Hirsova P, Gores GJ. Non-alcoholic steatohepatitis pathogenesis: Sublethal hepatocyte injury as a driver of liver inflammation. Gut. 2018; doi:10.1136/gutjnl-2017-315691.
  • Ibrahim SH, Robertson KD. Use of the CRISPR/Cas9-based epigenetic gene activation system in vivo: A new potential therapeutic modality. Hepatology 2018; doi:10.1002/hep.29860.
  • Gutierrez Sanchez LH, Tomita K, Guo Q, Furuta K, Alhuwaish H, Hirsova P, Baheti S, Alver B, Hlady R, Robertson KD, Ibrahim SH. Perinatal nutritional reprogramming of the epigenome promotes subsequent development of nonalcoholic steatohepatitis. Hepatology Communication. 2018; doi:10.1002/hep4.1265.
  • Guo Q, Furuta K, Lucien F, Gutierrez Sanchez LH, Hirsova P, Krishnan A, Kabashima A, Pavelko KD, Madden B, Alhuwaish H, Gao Y, Revzin A, Ibrahim SH. Integrin beta1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH. Journal of Hepatology. 2019; doi:10.1016/j.jhep.2019.07.019.
  • Ibrahim SH, Jonas MM, Taylor SA, Gutierrez Sanchez LH, Wolf JL, Sundaram SS. Liver diseases in the perinatal period: Interactions between mother and infant. Hepatology. 2020; doi:10.1002/hep.31109.

See a complete list of Dr. Ibrahim's publications on PubMed.