The Head and Neck Regenerative Medicine Laboratory, led by principal investigator David G. Lott, M.D., is a translational lab specifically designed for bench work innovation that can be directly applied to clinical medicine.

The Head and Neck Regenerative Medicine Lab spans basic and applied (translational) science, applied engineering science, medical device product development, clinical translational research, and ultimately end-use clinical application. This team systems paradigm facilitates full-spectrum, detailed and safe scientific advancement.

Our laboratory, which is based at Mayo Clinic's campus in Arizona, serves as the flagship lab for the head and neck region in the Center for Regenerative Medicine. It utilizes all components of regenerative medicine — scaffold generation, stem cell differentiation and acellular therapeutics — to pioneer processes and products for the regeneration of head and neck structures.

Ongoing research in our lab aims to treat laryngeal cancers, voice disorders, laryngeal trauma, and other head and neck conditions with regenerative cell-based therapies and bioengineered constructs. This research will restore the ability of patients to speak, breathe and swallow, improving their overall quality of life.


The Head and Neck Regenerative Medicine Laboratory is supported by funding from the Center for Regenerative Medicine at Mayo Clinic and gifts from benefactors.

About Dr. Lott

Dr. Lott is an otolaryngologist at Mayo Clinic in Phoenix, Arizona, who specializes in laryngeal surgery. Dr. Lott is also an associate professor of otolaryngology at the Mayo Clinic College of Medicine and Science and is the associate director of the Center for Regenerative Medicine at Mayo Clinic in Arizona.