Image of Dr. David G. Lott of Mayo Clinic Bench work innovation

With a focus on regenerative cell-based therapies and bioengineered constructs for head and neck conditions, our lab is pioneering work that will restore the ability of patients to speak, breathe and swallow.

Overview

The Head and Neck Regenerative Medicine Laboratory, led by principal investigator David G. Lott, M.D., is a translational lab specifically designed for bench work innovation that can be directly applied to clinical medicine.

The Head and Neck Regenerative Medicine Lab spans basic and applied (translational) science, applied engineering science, medical device product development, clinical translational research, and ultimately end-use clinical application. This team systems paradigm facilitates full-spectrum, detailed and safe scientific advancement, including pioneering work in larynx and tracheal transplantation.

Our laboratory, which is based at Mayo Clinic's campus in Arizona, serves as the flagship lab for the head and neck region in the Center for Regenerative Medicine. It utilizes all components of regenerative medicine — scaffold generation, stem cell differentiation and acellular therapeutics — to develop processes and products for the regeneration of head and neck structures. By advancing larynx transplantation, 3D-printed implants and regeneration, Dr. Lott and his team could restore function to people whose voice box has been damaged or removed.

Ongoing research in our lab aims to treat laryngeal cancers, voice disorders, laryngeal trauma, and other head and neck conditions with regenerative cell-based therapies and bioengineered constructs. This research will restore the ability of patients to speak, breathe and swallow, improving their overall quality of life.

Funding

The Head and Neck Regenerative Medicine Laboratory is supported by funding from the National Institutes of Health, the Center for Regenerative Medicine at Mayo Clinic and gifts from benefactors.

About Dr. Lott

Dr. Lott is an otolaryngologist at Mayo Clinic in Phoenix/Scottsdale, Arizona, who specializes in laryngeal surgery. Dr. Lott is a professor of otolaryngology at Mayo Clinic College of Medicine and Science. He is a consultant in the Department of Otolaryngology (ENT)/Head and Neck Surgery and serves as chair of the Division of Laryngology at Mayo Clinic in Arizona. His clinical practice includes voice and swallowing restoration, laryngeal cancer, and laryngotracheal reconstruction.

Dr. Lott is the associate director of the Center for Regenerative Medicine at Mayo Clinic in Phoenix/Scottsdale, Arizona. He is faculty for both the Clinical and Translational Science and Regenerative Sciences tracks within the Mayo Clinic Graduate School of Biomedical Sciences.