Projects

Projects in the Aging and Dementia Imaging Research Lab led by Clifford R. Jack, M.D., at Mayo Clinic focus on neuroimaging to diagnose Alzheimer's disease and related dementias before symptoms occur to treat the disease more effectively.

The ADIR lab uses modern brain-imaging modalities including amyloid positron emission tomography (PET), fluorodeoxyglucose (FDG) PET, tau PET, anatomic magnetic resonance imaging (MRI), diffusion imaging, perfusion imaging, task-free functional MRI and magnetic resonance spectroscopy, along with clinical, psychometric, genetic and neuropathologic information.

Mayo Clinic Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry

• Structural magnetic resonance imaging
• Magnetic resonance spectroscopy
• Functional magnetic resonance imaging (MRI)
• Positron emission tomography (PET)
• Arterial spin labeling perfusion
• Diffusion tensor imaging
• Other dementias

Multisite studies

The Aging and Dementia Imaging Research Lab serves as the magnetic resonance center for large multisite observational and interventional studies including A4, AHEAD 3-45 and the Jackson Heart Study.

• A4 Study
• AHEAD 3-45 Study
• Alzheimer Biomarker Consortium – Down Syndrome (ABC-DS)
• Alzheimer's Prevention Initiative (API)
• Alzheimer's Clinical Trial Consortium for Down Syndrome (ACTC-DS) – Trial Ready Cohort Down syndrome (TRC-DS)
• Alzheimer's Disease Neuroimaging Initiative (ADNI)
• ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
• Atherosclerosis Risk in Communities (ARIC)
• BRINK (Brain In Kidney Disease) Memory Study 2.0
• Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on Recovery (DISCOVERY)
• Dominantly Inherited Alzheimer Network (DIAN)
• Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU)
• Early Post-Menopausal Hormone Therapy for Preventing Alzheimer's Disease (KEEPS Continuation)
• Efficacy and Mechanism of Combined Aerobic Exercise and Cognitive Training in MCI (ACT Trial)
• Jackson Heart Study (JHS)
• Longitudinal Early-onset AD Study (LEADS)
• Mayo Clinic Alzheimer's Disease Research Center (ADRC)
• Mayo Clinic Study of Aging (MCSA)
• Neurodegeneration in Aging Down Syndrome (NiAD)
• North American Prodromal Synucleinopathy Consortium for RBD, Stage 2 (NAPS2)
• SCORE on Sex Differences
• Standardized Centralized Alzheimer's & Related Dementias Neuroimaging (SCAN)
• Understanding the long term impact of COVID-19 on the brain by advanced MR imaging and spectroscopy (COVID-BRAIN)
• U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER)

Animal and other studies

• High-Field MRI and Spectroscopy of Transgenic Alzheimer's Mice — Mayo Clinic and University of Minnesota Biotechnology Partnership, with Michael Garwood, Ph.D.

Past studies

• Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)
• Allon PSP (AL108231)
• Frontal Temporal Lobe Dementia (FTLD)
• Genetics of Microangiopathic Brain Injury (GMBI)
• IGIV
• Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)
• Pfizer A9951002
• Therapeutic Efficacy of Vitamin E and Donepezil in Mild Cognitive Impairment
• Therapeutic Efficacy of Milameline for Alzheimer's Disease
• Valproate