Research projects in the Aging and Dementia Imaging Lab led by Clifford R. Jack, M.D., at Mayo Clinic focus on neuroimaging to diagnose Alzheimer's disease and related dementias before symptoms occur to more effectively treat the disease.

We use modern brain-imaging modalities including amyloid positron emission tomography (PET), fluorodeoxyglucose (FDG) PET, tau PET, anatomic magnetic resonance imaging (MRI), diffusion imaging, perfusion imaging, task-free functional MRI and magnetic resonance spectroscopy, along with clinical, psychometric, genetic and neuropathologic information.

Mayo Clinic Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry

  • Structural magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Functional magnetic resonance imaging (MRI)
  • Positron emission tomography (PET)
  • Arterial spin labeling perfusion
  • Diffusion tensor imaging
  • Other dementias

Multisite studies

Dr. Jack's Aging and Dementia Imaging Lab serves as the magnetic resonance center for large multisite observational and interventional studies including, A4, A345 and the Jackson Heart Study.

Animal and other studies

  • High-Field MRI and Spectroscopy of Transgenic Alzheimer's Mice — Mayo Clinic and University of Minnesota Biotechnology Partnership, with Michael Garwood, Ph.D.

Past studies

  • Therapeutic Efficacy of Vitamin E and Donepezil in Mild Cognitive Impairment
  • Therapeutic Efficacy of Milameline for Alzheimer's Disease