The Aging and Dementia Imaging Laboratory led by Clifford R. Jack, M.D., is engaged in brain-imaging research in cognitive aging and Alzheimer's disease and related disorders. The lab uses imaging to study the biology of brain aging and cognitive impairment. We also develop image-processing algorithms for quantitatively measuring the information obtained from brain imaging.

Dr. Jack's research team studies what constitutes normal aging of the brain and how pathological aging and neurodegenerative diseases differ from normal aging. Specific goals include: understanding how various imaging measures relate to neuropathology; how imaging relates to cognitive, behavior and specific phenotypic abnormalities cross-sectionally; how imaging relates to longitudinal change on cognition and behavior; and how longitudinal change on imaging relates to simultaneous longitudinal change on cognition and behavior.

Our clinical imaging research is tightly integrated into National Institutes of Health-funded longitudinal clinical and epidemiologic research projects in normal aging, Alzheimer's disease, and other dementias through the Mayo Clinic Alzheimer's Disease Patient Registry and Alzheimer's Disease Research Center. We also collaborate with a number of investigators outside Mayo Clinic, and the Aging and Dementia Imaging Lab serves as the imaging center for several large national multisite studies.


Dr. Jack's Aging and Dementia Imaging Laboratory works closely with these Mayo Clinic research groups:

About Dr. Jack

Dr. Jack is a radiologist in the Department of Radiology and is a professor of diagnostic radiology at the Mayo Clinic College of Medicine and Science, Rochester, Minnesota. His research interests include using imaging to identify pathological processes that occur in the living person prior to cognitive aging and dementia. His lab also seeks to help investigators develop treatments for these diseases before clinical symptoms occur. Dr. Jack is also focused on developing and validating tests for accurate diagnosis of Alzheimer's disease and related dementias and developing eventual interventions.