Mayo Clinic Study of Aging

Mayo Clinic Study of Aging logo

The Mayo Clinic Study of Aging and the Alzheimer's Disease Research Center at Mayo Clinic are offering a data sharing opportunity for qualified researchers.

About the study

Since it began in 2004, the Mayo Clinic Study of Aging has provided:

  • Important information about cognitive and brain aging trajectories
  • Characterization of and outcomes for mild cognitive impairment
  • Insights into vascular, psychiatric and inflammatory predictors of cognitive impairment
  • Better understanding of in vivo brain pathology

The broad long-term goals of the Mayo Clinic Study of Aging are to:

  • Develop tools to predict and prevent cognitive decline and dementia
  • Develop risk-prediction models for cognitive impairment
  • Conduct aging-related research to promote successful aging

The study has already accomplished several of its original goals, including:

  • Estimating the prevalence and incidence of mild cognitive impairment and dementia, including Alzheimer's disease and other dementias
  • Identifying protective factors and risk factors for these conditions in Olmsted County, Minnesota
  • Determining long-term outcomes of these conditions

The Mayo Clinic Study of Aging has enrolled more than 5,000 residents of Olmsted County, Minnesota, without a previous diagnosis of dementia in their medical record who were 30 to 89 years old at the time of enrollment. About 3,100 people are active participants in the study.

The Alzheimer's Disease Research Center actively follows and examines yearly about 600 people with mild cognitive impairment and dementia related to Alzheimer's disease, cerebrovascular disease, Lewy body disease and frontotemporal degeneration.

Each study participant undergoes an extensive clinical evaluation to determine whether they have mild cognitive impairment or dementia or are cognitively normal at the time of enrollment. They are evaluated about every 15 to 30 months to determine if they have developed new onset of mild cognitive impairment or dementia.

About 50% to 60% of participants consent to brain magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging using 11C Pittsburgh compound-B 18F-AV-1451 tau and 18F-fluorodeoxyglucose to assess cerebrovascular disease, neurodegeneration, amyloid deposition and brain metabolism. About 25% consent to undergo a lumber puncture to measure amyloid and tau metabolites in cerebrospinal fluid.

Research related to the study has resulted in numerous peer-reviewed publications and extensive national and international collaborations.

The Mayo Clinic Study of Aging and the Alzheimer's Disease Research Center provide a rich database of clinical, biomarker and neuropathological experience with cognitive aging. Data include information about cognitive and brain-aging trajectories, characterization of and outcomes for mild cognitive impairment and dementia, and insights into vascular, psychiatric and inflammatory predictors of cognitive impairment and in vivo brain pathology.

Study of Aging focus areas

Research area Faculty
Mild cognitive impairment characterization
Imaging (MRI)
PET imaging, amyloid and tau imaging
REM sleep behavior disorders and non-Alzheimer's dementias Bradley F. Boeve, M.D.
Psychiatric risk factors, exercise Yonas E. Geda, M.D.
Biomarker development Michelle M. Mielke, Ph.D.
Diabetes, cardiovascular disease, inflammatory markers, dietary factors Michelle M. Mielke, Ph.D.
Neuropathology Dennis W. Dickson, M.D.
Genetic markers Nilufer Taner, M.D., Ph.D.
Tau protein Leonard Petrucelli, Ph.D.

Data sharing for researchers

Data from the Mayo Clinic Study of Aging and the Alzheimer's Disease Research Center are now available to qualified academic and industry researchers to maximize the value of the collected data.

Qualified researchers interested in these data sharing opportunities can submit a request to the Mayo Clinic Study of Aging/Alzheimer's Disease Research Center Executive Committee. Each request is reviewed to determine eligibility.

Contact

For more information about the Mayo Clinic Study of Aging or the Alzheimer's Disease Research Center, contact:

Alzheimer's Disease Research Center

  • Mayo Clinic
    4111 Highway 52 North
    Rochester, MN 55901
  • Phone: 507-284-1324

For more information about data sharing or to request data from the Mayo Clinic Study of Aging, contact:

Data Sharing Coordinator

  • Alzheimer's Disease Research Center
    Mayo Clinic
    4111 Highway 52 North
    Rochester, MN 55901
  • Phone: 507-293-9576
  • Fax: 507-538-0878
  • Email: mcsaadrcdatasharing@mayo.edu